Pro- and anti-inflammatory mediators Flashcards
1
Q
what is key factor for development of sepsis?
A
inflammation
2
Q
How is infection/injury controlled?
A
proinflammatory + anti-inflammatory mediators
= balance of these localize infection/ injury host tissues
3
Q
How are proinflammatory mediators facilitated?
A
- clearance injuring stimulus
- promotes resolution of injury
- process damaged tissues
4
Q
What do anti-inflamm mediators control?
A
intensity + duration inflamm response
5
Q
what happens when equilibrium of inflammtory process is losts?
A
systemic responses occur
6
Q
How is inflamm process in sepsis linked to coagulation system ?
A
- Pro-inflamm mediators - procoagulant + antifibrinolytic effects
- Anti-inflamm mediators - fibrinolytic effects
7
Q
What protein is a key factor in sepsis inflammation and what does it enhance ?
A
- Activated protein C
- enhances fibrinolysis
- inhibits inflamm
- decrease levels = many septic patients
