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21 fall: histology > lab 8 bone marrow > Flashcards

lab 8 bone marrow Flashcards

1
Q

In general, cells of the ____ series have round nuclei with dense, darkly stained, clumped chromatin and basophilic cytoplasm.

A

erythroid

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2
Q

As the ___ cell matures, the cytoplasm becomes hemoglobinized, i.e., more acidophilic and less basophilic, while the nucleus condenses, becomes smaller and is eventually extruded

A

erythroid

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3
Q

granulocytes as they mature

A

The cell nucleus is lighter purple and has a finer chromatin pattern.

The nuclear shape becomes successively flattened, eccentric, elongated and lobulated. The cytoplasm is initially basophilic and granular, but the intensity of basophilia decreases with maturation.

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4
Q

another name for Basophilic Erythroblast

A

Prorubricyte

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5
Q

another name for proeyrthoblast/ pronormoblast

A

Rubriblast

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6
Q

RBC maturation

A
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7
Q

what? and where

A
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8
Q

what

A
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9
Q

Rubriblast and Prorubricyte

A

proerythroblast, basophilic erythroblast

large cells with a darkly staining, round, centrally-located nucleus containing coarseand clumped chromatin

the cytoplasm is very basophilic (navy blue) and smooth.

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10
Q

The rubriblast(proerythroblast) differs from the prorubricyte(basophilic erythroblast) in that a prominent ____ will be present

A

nucleolus

a nucleolus appears as a different colored spot (typically blue) within the more purple staining nucleus.

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11
Q

Rubricyte

A

Polychromatophilic Erythroblast

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12
Q

rubricyte/ (Polychromatic Erythroblast)

A

This cell is smaller than the prorubricyte (Basophilic Erythroblast)

the nucleus: denser chromatin and it occupies a smaller portion of the cell.

Hemoglobin synthesis imparts a pink color, here and there, overall mottled or lavender appearance (polychromasia).

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13
Q

Metarubricyte or

A

Normoblast (Orthochromatic Erythroblast)

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14
Q

Normoblast (Orthochromatic Erythroblast) (metarubricyte)

A

smaller than a rubricyte. (Polychromatic Erythroblast)

Its nucleus contains very condensed (almost pyknotic) chromatin and is darkly stained.

Cytoplasm: pink or at least lighter in color due to the increased hemoglobin content.

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15
Q

Polychromatophil or

A

(Reticulocyte)

Polychromatophilic erythrocyte

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16
Q

Polychromatophil (Reticulocyte):

A

immature, anucleate red blood cell.

Cytoplasm is more lavender than a mature erythrocyte because of a decreased hemoglobin content.

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17
Q

A reticulocyte count is used to ____

A

assess regenerative response in anemic patients.

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18
Q

RBC terms per handout

A

Rubriblast –Proerythroblast
Prorubricyte –basophilic erythroblast
Rubricyte –polychromatic erythroblast
Metarubricyte–orthochromatic erythroblast
Polychromatophil -reticulocyte (polychromatophilic RBC)
Erythrocyte

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19
Q

Myeloid seriers

A 
Myeloblast
Progranulocyte (Promyelocyte)
Myelocyte
Metamyelocyte
Band Cell
Mature Segmented Granulocytes
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20
Q

Large cell with a round to oval nucleus and finely dispersed chromatin - euchromatic. Nucleoli may be present. The cytoplasm is basophilic and grainy.

A

myeloblast (hard to find)

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21
Q

In this cell, the nuclear chromatin is beginning to clump. Magenta or purple (azurophilic) granules are visible in the basophilic cytoplasm. Neutrophils, basophils, and eosinophils are indistinguishable up to and including this stage of development.

A

Promyelocyte)

22
Q

smaller than the progranulocyte. Its nucleus is usually oval and eccentrically situated. The nuclear chromatin is coarser. Specific granules develop in the cytoplasm.

A

Myelocyte.

23
Q

The nucleus begins to indent to form lobes (sausage- shaped) and the chromatin becomes denser. The cytoplasm is paler blue.

A

Metamyelocyte

24
Q

As the nucleus matures, it continues to indent to form a ____ or rod shape. The nucleus eventually becomes segmented in appearance. The cytoplasm is pink and specific granules may be seen.

A

band

Band Cells and Mature Segmented Granulocytes.

25
Q

stained with Giemsa

The erythroid precursor cells stain___ than the granulocytic cells and they are less ____

A

darker

numerus

26
Q

Difference between bone marrow of mammal and bird:

A

As in mammals, myelopoiesis occurs in the space outside of the vessels of the marrow.

In avian species: erythropoiesis takes place within the blood vessels of the marrow. The earliest red blood cell precursors are in close association with the endothelium of the vessel wall. As the cells mature, they move out towards the center.

27
Q

bone marrow in birds

A
28
Q

myeloid series

A
29
Q
A

Mature megakaryocyte

30
Q
A

Immature megakaryocyte

bone marrow

31
Q
A
  1. Mature megakaryocyte
32
Q
A

Early prorubricyte (Basophilic Erythroblast)

33
Q
A

Rubricytes (Polychromatic Erythroblast)

34
Q
A
  1. Rubricyte (Polychromatic Erythroblast)
35
Q
A

Metarubricyte (Orthochromatic Erythroblast)

36
Q
A

Metarubricyte (Orthochromatic Erythroblast) top cell

Rubricyte bottom cell

37
Q
A

Progranulocyte, late “a better example would have a centrally located nucleus.

38
Q
A

Metamyelocyte (with indented nucleus) & myelocyte (with oval nucleus)

39
Q
A

Metamyelocyte

40
Q
A

Band cell

41
Q
A

Band cell

42
Q
A

megakaryocyte

43
Q
A

osteoclast

44
Q
A

erythroid cell

granulocytic cells

45
Q
A

Polychromatophilic Erythroblast (Rubricyte)

Basophilic Erythroblast (Prorubricyte)

Orthochromatophilic Erythroblast (Metarubricyte/Normoblast)

46
Q
A

Promyelocyte

Progranulocyte

47
Q
A

Basophilic Myelocyte

48
Q
A

Neutrophilic

Myelocyte

49
Q
A

Late Neutrophilic Metamyelocyte

Neutrophilic Band Cell

50
Q

cat bone marrow

A
51
Q

plastic section

A

21 fall: histology (36 decks)

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