Pharmacology of anxiolytic drugs

Question 1

2 core symptoms of anxiety disorders

Answer 1

Fear and worry

Question 2

Fear is controlled by what part of brain?

Answer 2

Amygdala

Question 3

Worry is controlled by what part of brain?

Answer 3

Cortico-striatal thalamic-cortical circuit

Question 4

Fight or flight is controlled by what part of brain ?

Answer 4

PAG

Question 5

What is the main inhibitory transmitter in the brain?

Answer 5

GABA

Question 6

Action of BZD

Answer 6

Enhance GABA action

Question 7

Diazepam AKA

Answer 7

Valium

Question 8

Lorazepam AKA

Answer 8

Ativan

Question 9

What do BZD do?

Answer 9

Reduce anxiety and aggression
Muscle relax
Anticonvulsant
Anterograde amnesia

Question 10

BZD can cause

Answer 10

Respiratory depression

Question 11

SSRIs ______ serotonin

Answer 11

Increase

Question 12

What do you avoid in panic disorders?

Answer 12

BZD or sedating antihistamines, propranolol

Question 13

Manage PTSD Mild/<4 weeks of trauma

Answer 13

Watchful waiting

Question 14

Manage PTSD within 3 months of trauma

Answer 14

CBT or hypnotic medication

Question 15

More than 3 months after trauma PTSD

Answer 15

Trauma focussed CBT or EMDR

Question 16

How long do you use BZD for? Why ?

Answer 16

2-4 weeks

Risk of dependence