Neurobiology of mood disorders

Question 1

Appetitive / approach system is for

Answer 1

Seeking and approach behaviours (including pleasure)

Question 2

Appetitive approach system neurotransmitter

Answer 2

Dopamine

Question 3

Aversive defensive systems are for

Answer 3

Promoting survival in event of threat and fear/pain

Question 4

Aversive defensive system neurotransmitter

Answer 4

Serotonin

Question 5

People with childhood trauma with depression respond better to _______ and those without childhood trauma with depression respond better to _______.

Answer 5

Trauma: psychotherapy

No trauma: antidepressant

Question 6

4 regions implicated in mood disorders

Answer 6

Orbital frontal cortex (and ventromedial prefrontal cortex)
Dorsolateral prefrontal cortex
Hippocampus, amygdala
Anterior cingulate cortex

Question 7

What cytokines are elevated in depression

Answer 7

TNFa

IL6

Question 8

People with depression have ______ hippocampus volumes

Answer 8

Smaller

Question 9

People with high cortisol have a _______ hippocampus volume

Answer 9

Reduced