Microtubule Motor Proteins Flashcards
Which direction do kinesins transport cargo along microtubules? What is the term for this?
Positive end of microtubules ( anterograde)
Which direction do dyneins transport cargo along microtubules? What is the term for this?
Negative end (reterograde)
Do dyneins and kinesins require ATP to transport cargo?
Yes
What speed do kinesins tend to travel?
Travel approx 600nm / s
[can span most cells (10 - 100 um) in seconds]
What is the function of kinesin-1?
Organelle transport
What is the function of kinesin-2?
Organelle transport
What is the function of kinesin-5?
Sliding microtubules past each other, eg; in relation to chromosome separation and polar microtubules
What is the function of kinesin-13?
Disassmebly of microtubules from positive and negative ends by hydrolysing ATP
How are dyneins linked to their cargo?
Via the large protein complex, dynactin
What kind of cargo do dyneins transport?
Vesicles and chromosomes
Which of kinesins and dyneins are larger?
Dyneins are larger than kinesins
What are tau tanlges?
Abnormal tau aggregates and causes tau tangles which block microtubule transport
What disease are tau tangles associated with?
Alzheimer’s disease
Which end of the spindle microtubules are associated with the spindle poles?
Negative
What are the names of the microtubules that make up the spindle?
Kinetochore microtubules
Polar microtubules
Astral microtubules
