Receptor Tyrosine Kinases (RTKs) Flashcards
Give some examples of RTKs
Insulin receptor
Vascular endothelial growth factor receptor
Platelet derived growth factor receptor
Epidermal growth factor receptor
Give some examples of processes RTKs are involved with
Glycogen synthesis
New blood vessel growth
Embryonic development
Cell proliferation
Cell migration
Growth, proliferation and differentiation
How do RTKs and cytokine receptors differ?
RTKs have intrinsic kinase activity (kinase is part of receptor)
Cytokine receptors are linked to a kinase that is not a part of the receptor itself
What is the ligand for the epidermal growth factor receptor?
Epidermal growth factor (EGF)
What does EGF stand for?
Epidermal growth factor
Human EGF is a polypeptide of how many amino acids?
53 (small)
What does EGF signal for?
Regulation of cell growth, proliferation, differentiation
When tyrosine kinase interacts with the tail tyrosine residues, what does the tyrosine become?
phosphotyrosine (tyrosine phosphate)
due to phosphorylation
What medical consequence can a single point mutation in Ras have?
Colorectal cancer
What type of kinase is Raf?
serine/threonine kinase
What does MAPKK stand for?
Mitogen activated protein kinase kinase
What is another name for MEK?
MAPKK
What is another name for Raf?
MAPKKK
What is another name for ERK?
MAPK
What is the c-fos gene?
Early response gene leading to proliferation development
