Part 2

Question 1

Used to treat cardiac arrhythmia

Answer 1

Procainamide

Question 2

Hepatic metabolite of the parent drug Procainamide

Answer 2

NAPA

N-acetyl procainamide

Question 3

Used to treat generalized tonic clonic, simple, partial and complex partial seizures

Answer 3

Primidone

Question 4

Two active metabolites of primidone

Answer 4

Phenobarbital and

Phenylethylmalonamide

Question 5

Metabolite or cocaine

Answer 5

Benzoylecgonine

Question 6

Where is benzoylecgonine eliminated?

Answer 6

Urine

Question 7

What causes cocaine’s short life

Answer 7

Rapid hepatic hydrolysis to inactive metabolites

Question 8

Where does Lead accumulate? (3)

Answer 8

RBCs, BONES and NEURAL TISSUES

Question 9

Suitable for demonstrating lead toxicity (3)

Answer 9

Whole blood, Hair, and Urine

Question 10

Specimen which gives greatest sensitivity to lead and can detect exposure over time

Answer 10

WHOLE BLOOD

Question 11

Amount of lead in tubes with tan stoppers

Answer 11

No more than 0.25ug/dL

Question 12

Effect of contamination (e.g. extracted nucleic acid or carryover amplicons) to PCR assay

Answer 12

False positive

Question 13

What to do when contamination occurs in PCR assay

Answer 13

1. All equipment and work surfaces must be cleaned

2. New rgts (inc. primers) must be used

Question 14

Comparison of patient data with previous results

Answer 14

Delta checks

Question 15

Detects specimen mix-up and other errors

Answer 15

Delta checks

Question 16

When limit is exceeded during delta checks, mt must determine if due to

Answer 16

Medical change in patient or lab error

Question 17

Formula for Coefficient of Variation (CV)

Answer 17

(SD/mean) x 100

Question 18

The smaller the CV, the greater the___

Answer 18

Precision

Question 19

Control values increasing or decreasing for 6 consecutive runs

Answer 19

Trend

Question 20

What causes TREND

Answer 20

DETERIORATION OF REAGENTS/CTRL ; Progressive problem with the testing system or sample control

Question 21

6 consecutive control values on the same side of the mean

Answer 21

SHIFT

Question 22

What causes SHIFT

Answer 22

Sudden malfunction of an instrument

Question 23

When a limit of 2 SD is used, 5% of expected assay results fall above or below the limit

Answer 23

REASSAY

Question 24

Ctrls may deteriorate overtime when exposed to adverse temperatures or subjected to cx causing evaporation

Answer 24

Prepare NEW CONTROL and REASSAY

Question 25

Rgts may have evaporated or become contaminated

Answer 25

Prepare fresh REAGENTS and reassay

Question 26

Instrument may require repair

Answer 26

Recalibrate instrument

Question 27

Commercial controls used to verify accuracy and reliability of patient test results

Answer 27

External QC

Question 28

Electronic, internal, and procedural controls contained within the test system that ensures the reliability of the test system

Answer 28

Internal QC

Question 29

Manager makes all decisions without input from others; Quick decision-making; least acceptance and commitment from staff.; Poorest quality decisions.

Answer 29

Authoritative

Question 30

(+)
Manager makes decisions AFTER POOLING STAFF.; better quality and acceptance.

(-)
Decisions Takes longer. ; those in minority might feel ignored

Answer 30

DEMOCRATIC

Question 31

Abbreviate MALDITOF

Answer 31

Matrix-assisted laser desorption-ionization time-of-flight