Exam 3: Cancer Genomics

Question 1

What is a genome?

Answer 1

sequence of DNA, copy number variations, and structural changes to chromosomes.

Question 2

What is Epigenome?

Answer 2

Record of chemical changes to DNA and proteins. (chemical Modifications to DNA and histones)

Question 3

What describes the mRNA and MircoRNA expression patterns?

Answer 3

Transcriptome

Question 4

The entire set of proteins that is expressed by a genome or cell at a certain time?

Answer 4

Proteome

Question 5

What are the goals of Cancer Genomics?

Answer 5

1. Find new cancer drugs
2. find new therapeutic targets
3. move towards personalized cancer therapy

Question 6

What is the concept of Personalized Therapy?

Answer 6

Using information about a patients unique genetic makeup to tailor treatment s= to individual needs.

Question 7

Where do we stand with personalized therapy now?

Answer 7

There is still all of criticism for the methods because right now it isn’t looking very promising . Some patients don’t respond to treatment and others develop resistance.

Question 8

What are the levels of analysis in Cancer Genomics?

Answer 8

Genome
Epigenome
Transcriptome
Proteome