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hematology > LEUKOCYTE MORPHOLOGICAL ABNORMALITIES (GCA) > Flashcards

LEUKOCYTE MORPHOLOGICAL ABNORMALITIES (GCA) Flashcards

1
Q

Darkly staining metachromatic (purple-red) cytoplasmic granules in granulocytes (less often in monocytes and lymphocytes

A

ALDER-REILLY GRANULES (primary granules)

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2
Q

Abnormal large primary granules

A

ALDER-REILLY GRANULES (primary granules)

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3
Q

Granules contain degraded mucopolysaccharides due to an enzyme defect

A

ALDER-REILLY GRANULES (primary granules)

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4
Q

May resemble toxic granules (seen in infections and toxic states)

A

ALDER-REILLY GRANULES (primary granules)

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5
Q

Alder-Reilly anomaly Mucopolysaccharidoses (MPSs’)

A

ALDER-REILLY GRANULES (primary granules)

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6
Q

-Gray-blue spindle shaped inclusions in the cytoplasm

A

MAY-HEGGLIN GRANULES

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7
Q

-Large Dohle body-like inclusions in neutrophils,eosinophils, basophils, and monocytes

A

MAY-HEGGLIN GRANULES

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8
Q

-The basophilic Dohle body-like leukocyte inclusions are composed of precipitated myosin heavy chains (mRNA)

A

MAY-HEGGLIN GRANULES

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9
Q

-True Dohle bodies consist of lamellar rows of rough endoplasmic reticulum (rRNA)

A

MAY-HEGGLIN GRANULES

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10
Q

Giant red, blue, to grayish round inclusions in the cytoplasm

A

CHEDIAK-HIGASHI GRANULES

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11
Q

Giant lysosomal granules in granulocytes, monocytes,and lymphocytes

A

CHEDIAK-HIGASHI GRANULES

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12
Q

Cells in the body are affected and exhibit abnormally large lysosomes, which contain fused dysfunctional granules

A

CHEDIAK-HIGASHI GRANULES

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13
Q

are cytoplasmic inclusions that resemble the fused lysosomal granules

A

Pseudo-Chediak-Higashi granules

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14
Q

All cancerous

A

Chediak-higashi granules

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15
Q

Pink or red shaped cytoplasmic granules; found in myeloid and monocytic series only Fused primary granules (peroxidase stain positive)

A

AUER RODS

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16
Q

bundle of auer rods (seen in acute promyelocytic leukemia(APL); M3; also associated with DIC)

A

Faggot Cells

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17
Q

Acute myelogenous leukemia (AML, M1 and M2) Acute promyelocytic leukemia (APL, M3) Acute myelomonocytic leukemia (AMML, M4) [AML 1-7]

A

AEUR RODS

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18
Q

-Appears as dark, blue-black granules in the cytoplasm of neutrophils, usually in segmented and band forms

A

TOXIC GRANULATION (primary/reactive granules)

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19
Q

-Granulation may represent the precipitation of ribosomal protein (RNA) caused by metabolic toxicity within the cells

A

TOXIC GRANULATION (primary/reactive granules)

20
Q

Are peroxidase positive and reflect an increase in acid mucosubstance within primary, azurophilic granules that may enhance bactericidal activity

A

TOXIC GRANULATION (primary/reactive granules)

21
Q

Scale of toxic granulation?

A

1+ to 4+

22
Q

what is the severe scale in toxic granulation?

A

4+

23
Q

WHAT CAN TOXIC GRANULATION CAN MIMIC?

A

ALDER-REILLY ANOMALY

24
Q

Inflammations Infections Toxic states Burns Malignant disorders

A

Toxic Granulation

25
Q

Are light/pale blue round or elongated cytoplasmic inclusions between 1-5 um consisting of remnants of ribosomal ribonucleic acid (rRNA) arranged in parallel row; close to cellular membranes

A

DOHLE-AMATO BODIES/DOHLE BODIES

26
Q

-Are typically found in band and segmented neutrophils and can appear together with toxic granulations; can be seen in eosinophils, basophils, monocytes, and lymphocytes

A

DOHLE-AMATO BODIES/DOHLE BODIES

27
Q

Localized failure of cytoplasmic maturation

A

DOHLE-AMATO BODIES/DOHLE BODIES

28
Q

which granulocytes cytoplasmic abnormalities has a PAS reaction positive

A

DOHLE-AMATO BODIES/DOHLE BODIES

29
Q

which granulocytes cytoplasmic abnormalities may be confused with May-Hegglin granules

A

DOHLE-AMATO BODIES/DOHLE BODIES

30
Q

-A delay in preparing the blood film after collection may affect Dohle body appearance in that they are more grey than blue or in some cases may not be visible

A

DOHLE-AMATO BODIES/DOHLE BODIES

31
Q

which granulocytes cytoplasmic abnormalities can be seen in pregnant patients?

A

DOHLE-AMATO BODIES/DOHLE BODIES

32
Q

Autophagocytic vacuoles Tend to be small

A

CYTOPLASMIC VACUOLATIONS (holes/vacuoles)

33
Q

Tend to be large (up to 6 um) and often accompanied by toxic granulation induced by either bacteria or fungi are suggestive of sepsis

A

phagocytic vacuoles

34
Q

water has been lost and the chromatin becomes dense and -dark

A

PYKNOTIC AND NECROTIC CELLS

35
Q

i in neutrophils generally indicate imminent cell death In a pyknotic nucleus

A

pyknotic nuclei

36
Q

-Increased numbers of pyknotic or necrotic cells suggest that an

A

extended amount of time has elapsed between blood collection and blood film preparation

37
Q

-Necrotic nuclei are found in

A

dead neutrophils/necrobiotic neutrophils; they are rounded nuclear fragments with no filaments and no chromatin pattern

38
Q

-Is a result of osmotic swelling of the cytoplasm or by increased adhesion to the glass slide in stimulated neutrophils

A

CYTOPLASMIC SWELLING

39
Q

-Regardless of the cause, the result is a variation in neutrophil size or neutrophil anisocytosis

A

CYTOPLASMIC SWELLING

40
Q

Are small, obligate, intracellular bacteria transmitted by ticks to humans and other vertebrate hosts

A

EHRLICHIA AND ANAPLASMA

41
Q

These organisms grow as a cluster (morulae) in neutrophils and monocytes

A

EHRLICHIA AND ANAPLASMA

42
Q

can be mistaken for Dohle bodies in neutrophils can be mistaken for Dohle bodies in neutrophils

A

Morulae(cluster)

43
Q

Anaplasma phagocytophilum and rarely in

A

Ehrlichia ewingii (neutrophils)

44
Q

is transmitted by the black-legged tick (Ixodes scapularis) and the western black-legged tick (I. pacificus)

A

Human granulocytic erlichiosis(HGE)

45
Q

is a fungus; this organism lives intracellularly in cells of the mononuclear phagocyte system, cells of the bone marrow, or cells from sputum or effusion specimens

A

HISTOPLASMA (gardening)

H. capsulatum

46
Q

The fungus appears as a tiny oval body with a clear halo surrounding a small nucleus

A

HISTOPLASMA (gardening)

hematology (8 decks)

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