W7 - Metabolism

Question 1

What is the relation between parent and metabolite compound

Answer 1

There is an increase in water solubility and increase in biological activity in the parent compound

while the metabolite

has a decrease in biological activity and the nature of its activity changes

Question 2

What is a phase 1 reaction

Answer 2

it is a change in the structure of a molecule

Question 3

what are the three main reactions that alter drug structure

Answer 3

oxidation

reduction

hydrolysis

Question 4

what are phase 2 reactions

Answer 4

reactions involving the formation of a covalent bond which results in H20 conjugate to be excreted

Question 5

describe the activity of products of phase 2 compounds

Answer 5

phase 2 metabolism are predominantly inactive however in some cases activity retained