NONUNIONS Flashcards
cessation of both the endosteal and periosteal healing responses w/o bridging callus
nonunion
radiographic nonprogression of healing at how many months?
3 months
consolidation in poor position is called?
malunion
intermediate that is not bone and prevents bone to bone healing?
pseudoarthroses or fibrocartilaginous
bone production
stem cell differentiation
osteogenesis
cellular recruitment
induce new bone
osteoinductive
mesenchymal stem cells can differentiate most importantly into?
bone marrow and periosteum
location matters
stem cells require support cells that constitute the maintain proper function
primitive at endosteal ends
survival affected by disease
increased damage found in DM
all affected by this term?
niche
these cells are used in mechanosensing?
osteocytes
inner layer of periosteum is called?
Cambria, MSC found here
extravascular fibrin deposits, fx hematoma
limits hemorrhage
growth factors
rapidly cleared
no longer present at fx site by time of vascular and osseous union
fibrin deposition
methylgoxal
elevated in DM2
modifies plasminogen, with fibrin binding vs plasminogen cleavage
characteristics of?
reactive oxygen species
callus present
inadequate fixation
motion present
what is this type to aseptic nonunion, hypertrophic or atrophic?
hypertrophic
no callus
soft tissue imposition
avascular
de vascular adjacent bone fragments
what is this type of aseptic nonunion, hypertrophic or atrophic?
atrophic
major consideration in clinical diagnosis?
rule out superficial infection
