PROS AND CONS of therapeutics Flashcards
1
Q
Small molecule
A
- Does it have importance in literature
- Reversible inhibition?
- Desirable mechanism of action
2
Q
PROTAC
A
- Small molecule which can remove unwanted proteins Intra/extracellular target – easy or difficult?
- Desire to fully degrade target?
- Any safety considerations
3
Q
Antibody
A
- Intra/extracellular target – easy or difficult?
* Pharma and tools confirm feasibility?
4
Q
Antisense oligonucleotide
A
- Any risk associated
- Delivery can be difficult depending on target
- System delivery difficult in CNS
- Cost of goods?
5
Q
Peptide
A
- Cell penetration is a challenge
* Feasibility?
6
Q
Gene editing/CRISPR
A
- Risks associated with complete irreversible known down of target
- Off target editing risk
7
Q
Cell therapy
A
• Possible to identify a cell type?
