Questions to consider when proposing a new target Flashcards
1
Q
Testing a hypothesis
A
- How modulation of the target (potentiation or inhibition) will drive clinical efficacy
- Why will this drug be better than existing
2
Q
What evidence links target to disease?
A
- Ideally human genetic evidence but also
- Clinical precedence (a target already explored)
- Expression in disease
- Activity in disease
3
Q
Thinking of the patient
A
- What patient group would benefit
- How will we show the drug works?
- How will you show target engagement?
- Are there any safety related concerns
4
Q
How will you find compounds that bind and alter the function of target?
A
- How will you identify compounds that you can optimise?
- What analysis would you run and in what order?
- Assess feasibility of analysis
- What reagents you need
5
Q
Competitor environment
A
- Are there any activities relating to target in other companies?
- Can we learn anything from these?
- How will we compare to competition
