11-5

Question 1

mood WITHOUT abnormally high mood periods

Answer 1

Depressive Disorders

Question 2

> 1 major depressive episode (MDE) and cannot have a history of mania or hypomania (never swings to opposite mood)

Answer 2

Major Depressive Disorder

Question 3

unipolar depression

Answer 3

Major Depressive Disorder

Question 4

2 weeks of >5 affective, neuro-vegetative, or cognitive symptoms

Answer 4

Major Depressive Episode

Question 5

Affective symptoms of MDE

Answer 5

depressed mood

anhedonia (lack of pleasure)

Question 6

Neuro-vegetative symptoms of MDE

Answer 6

significant weight change
in/hypersomnia
loss of energy

Question 7

Cognitive symptoms of MDE

Answer 7

psychomotor changes
feeling guilty/worthless
decreased concentration
thoughts of death/suicidal ideation

Question 8

Risk of developing MDD

Answer 8

gen. pop. = 10%
relative (1st degree) = 20%
MZ co-twin with MDD = 30%

Question 9

MDD Neurobiology

Answer 9

^ Amygdala
^ HPAA
^ Cortisol
^ Cytokines

v Hippocampus
v Prefrontal Cortex
v Monoamines (dopamine & serotonin)

Question 10

psychotherapy (CBT) and antidepressants (^ serotonin and norepinephrine)

Answer 10

MDD treatments

Question 11

most popular class of ADs with benign side effects 
(ex: Fluoxetine AKA Prozac)

Answer 11

SSRIs

Question 12

not as affective as SSRIs but also has benign side effects

ex: Venlafaxine AKA Effexor

Answer 12

SNRIs

Question 13

Serotonin and Norepinephrine reuptake inhibitors, less serotonin and more norepinephrine, cardiac side effects

Answer 13

TCAs (Tricyclic Antidepressants)

Question 14

prevent enzyme degradation, diet restrictions to avoid tyramine-induces hypertension

Answer 14

MAOIs

Question 15

must experience at least 1 maniac episode, symptoms >1 wk (or hospitalization) that case marked impairment in functioning,

Answer 15

Bipolar I Disorder (BPI)

Question 16

abnormally elevated mood (or irritability) PLUS increased energy and 3 additional symptoms

Answer 16

Manic Episode

Question 17

Manic episodes without MDE (uncommon)

Manic episodes with alternating MDE (common)

Answer 17

BPI

Question 18

Risk of developing BPI

Answer 18

gen. pop. = 1%
relative (1st degree) = 20%
MZ co-twin with BPI = 80%

Question 19

more genetically controlled than MDD and manic episodes involve increased monoaminergic activitiy

Answer 19

BPI

Question 20

Mood stabilizer: treatment of Manic Episodes

Answer 20

lithium
anticonvulsants
antipsychotics

Question 21

treatment of bipolar MDEs

Answer 21

antidepressants with mood stabilizer

Question 22

ONLY FDA-approved drugs for BP depression

Answer 22

antipsychotics (different for those used to treat mania)

Question 23

experiencing at lease 1 MDE and 1 hypomanic episode

Answer 23

Bipolar II Disorder

Question 24

does not cause marked impairment in function, changed of mood uncharacteristic of person and last >4 days

Answer 24

Hypomanic episode

Question 25

MDEs with hypomania

Answer 25

BPII

Question 26

the more disruptive problem in BPII

Answer 26

depressed phase

Question 27

treatment same as BPI with focus on bipolar depressive drugs

Answer 27

BPII treatments

Question 28

>2 years, experiences periods of hypomanic symptoms that fluctuate with periods of depressive symptoms

Answer 28

Cyclothymic Disorder

Question 29

similar to BPI but mood shifts are not as extreme

Answer 29

Cyclothymic Disorder

Question 30

treated with mood stabilizers just like BPI

Answer 30

Cyclothymic Disorder

Question 31

alternating symptoms of dysthymic and hypomanic

Answer 31

Cyclothymic Disorder

Question 32

Mnemonic for MDE

Answer 32

SIG-E-CAPS: sleep change interest loss guilt energy problem concentration poor appetite change psychomotor changes suicidal ideation

Question 33

chronic depression, dysthymia and/or MDEs for 2+ yrs without interceding euthymia during that period

Answer 33

Persistent Depressive Disorder

Question 34

Premenstral mood lability

Answer 34

Premenstrual Dysphoric Disorder

Question 35

severe and persistent irritability in child

Answer 35

Disruptive Mood Dysregulation Disorder

Question 36

Mania (always) + MDE (usually)

Answer 36

BPI

Question 37

MDE + hypomania

Answer 37

BPII

Question 38

Hypomanic + Dysthymic symptoms

Answer 38

Cyclothymia

Question 39

Mnemonic for Manic Symptom

Answer 39

DIG FAST: Distractibility Iressponsibility Gradiosoity Flight of ideas (racing thoughts) ^ Activity (goal-direct) v Sleep Talkativeness