11 Flashcards
(23 cards)
FDA approved SSRIs for PTSD
sertraline
paroxetine
onset age for bipolar 1 vs 2
1- 18
2- 20s
risk of future episodes if first episode is mania vs depression
mania- 70%
depression- 50%
Since these type of antidepressants were introduced, studies have shown an increased switch rate & an
increase in the number
of rapid cycling cases
TCAs and SNRIs
Of all the antidepresants, using this one appears to carry the least risk
of inducing a manic episode
buproprion
meds to treat acute mania
- lithium
- depakote
- carbamazepine
- ziprasidone
- quetiapine
- asenapine
meds to treat bipolar maintencane
- lithium
- lamotrigine
- quetiapine
- olanzapine
- abilify
meds to treat bipolar depression
- lithium
- lamotrigine
- lorazadone
- quetiapine
- symbyax
While often used as an adjunct treatment of major depression,
this SGA is NOT shown to be beneficial in the treatment of bipolar depression
abilify
Often this symptom heralds
the onset of a new manic episode
decreased need for sleep
The washout period when
switching from an MAOI
to any SSRI is this
2 weeks
SSRIs or venlafaxine (effexor) may cause these common side effects which NaSSA’s 5HT3 antagonism may help reduce or remove
GI
Onset of therapeutic effect on insomnia and anxiety is typically in this time period for mirtzapeine
immediate
Fluoxetine (prozac), paroxetine (paxil), bupropion (wellbutrin), duloxetine (cymbalta) and other medications may increase all TCA’s concentration by
inhibiting this p450 enzyme
2D6
Blood levels should be drawn about this many hours after the last dose
12 hrs
To confirm therapeutic levels after starting lithium or increasing the dose, a lithium level
should be done after this
number of days
5 days
Before starting a male patient
on Divalproex Sodium
(Depakote), these two
lab tests should be done
LFTs and platelets
trough levels should be drawn at how many hours of immediate vs extended release of depakote
IR- 12 hrs
ER- 18 hrs
Carbamazepine (tegretol) has a black box warning for these two rare (~1/100,000 = 0.001%) but serious side effects on the hematopoietic system
agranulocytosis & aplastic anemia?
Patients who start taking lamotrigine (lamictal) have a this % risk of developing a benign rash
10%
This SGA has FDA indication to treat acute mania & must be taken sublingually because if it is swallowed only ~5% will be bioavailable due to 1st pass liver metabolism
asenapine
which antipsychotics are available in long acting injectable form
risperidone
palliperodone
olanzapine
abilify
antiemetic medication(s) is/are a D2 blocker(s) and may cause EPS or TD
Prochlorperazine (Compazine)
Metoclopramide (Reglan)
Droperidol (Inapsine)
Promethazine (Phenergan)
