11 Flashcards

(23 cards)

1
Q

FDA approved SSRIs for PTSD

A

sertraline

paroxetine

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2
Q

onset age for bipolar 1 vs 2

A

1- 18

2- 20s

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3
Q

risk of future episodes if first episode is mania vs depression

A

mania- 70%

depression- 50%

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4
Q

Since these type of antidepressants were introduced, studies have shown an increased switch rate & an
increase in the number
of rapid cycling cases

A

TCAs and SNRIs

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5
Q

Of all the antidepresants, using this one appears to carry the least risk
of inducing a manic episode

A

buproprion

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6
Q

meds to treat acute mania

A
  • lithium
  • depakote
  • carbamazepine
  • ziprasidone
  • quetiapine
  • asenapine
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7
Q

meds to treat bipolar maintencane

A
  • lithium
  • lamotrigine
  • quetiapine
  • olanzapine
  • abilify
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8
Q

meds to treat bipolar depression

A
  • lithium
  • lamotrigine
  • lorazadone
  • quetiapine
  • symbyax
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9
Q

While often used as an adjunct treatment of major depression,
this SGA is NOT shown to be beneficial in the treatment of bipolar depression

A

abilify

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10
Q

Often this symptom heralds

the onset of a new manic episode

A

decreased need for sleep

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11
Q

The washout period when
switching from an MAOI
to any SSRI is this

A

2 weeks

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12
Q

SSRIs or venlafaxine (effexor) may cause these common side effects which NaSSA’s 5HT3 antagonism may help reduce or remove

A

GI

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13
Q

Onset of therapeutic effect on insomnia and anxiety is typically in this time period for mirtzapeine

A

immediate

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14
Q

Fluoxetine (prozac), paroxetine (paxil), bupropion (wellbutrin), duloxetine (cymbalta) and other medications may increase all TCA’s concentration by
inhibiting this p450 enzyme

A

2D6

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15
Q

Blood levels should be drawn about this many hours after the last dose

A

12 hrs

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16
Q

To confirm therapeutic levels after starting lithium or increasing the dose, a lithium level
should be done after this
number of days

17
Q

Before starting a male patient
on Divalproex Sodium
(Depakote), these two
lab tests should be done

A

LFTs and platelets

18
Q

trough levels should be drawn at how many hours of immediate vs extended release of depakote

A

IR- 12 hrs

ER- 18 hrs

19
Q
Carbamazepine (tegretol) has a 
black box warning for these two 
rare (~1/100,000 = 0.001%) 
but serious side effects on 
the hematopoietic system
A

agranulocytosis & aplastic anemia?

20
Q

Patients who start taking lamotrigine (lamictal) have a this % risk of developing a benign rash

21
Q

This SGA has FDA indication to treat acute mania & must be taken sublingually because if it is swallowed only ~5% will be bioavailable due to 1st pass liver metabolism

22
Q

which antipsychotics are available in long acting injectable form

A

risperidone
palliperodone
olanzapine
abilify

23
Q

antiemetic medication(s) is/are a D2 blocker(s) and may cause EPS or TD

A

Prochlorperazine (Compazine)
Metoclopramide (Reglan)
Droperidol (Inapsine)
Promethazine (Phenergan)