Lec 10 Flashcards
what does DTH stand for?
Delayed-Type Hypersensitivity Reaction
Systemic Lupus Erythematosus is an example of what type of hypersensitivity?
Type III
Rheumatoid Arthritis is an example of what type of hypersensitivity?
Type IV
Multiple Sclerosis is an example of what type of hypersensitivity?
Type IV
Type 1 Diabetes is an example of what type of hypersensitivity?
Type IV
Inflammatory bowel disease is an example of what type of hypersensitivity?
Type IV
Therapeutic approaches to halting immune responses to ourselves include (multiple answers):
a. Blocking CCR5 agonists
b. Blocking co-stimulation by CTLA-4
c. Blocking CD3 antagonists
d. Blocking B-cell activation by inhibiting CTL
e. Blocking T-cell activation by inhibiting IL-2
f. Blocking inflammation markers expressed by APC from being exerted on the environment (e.g. IL-17, TNF, IL-6)
g. Blocking adhesion which contributes to inflammation
h. Blocking mast cells from producing histamines and heparin
b,e,f,g
when dealing with transplantation rejections (cells, tissues, organs, etc.), what is the indicator for rejection?
antibody response
Failure/loss of ability to produce antigens is one of the ways ____ escape our immune defenses. the inability to produce antigens results in lack of ___ recognition
tumors
T-cell
Mutations/loss in MHC genes needed for antigen processing is one of the ways ___ escape our immune defenses. This results in lack of ___ recognition
tumors
T-cell
Production of immune-suppressive proteins such as inhibitory ligands (PD-L1) and immunosuppressive cytokines (TGF-beta) is one of the ways ___ escape our immune defenses. This results in inhibition of ____ activation
tumors
T-cell
Among current tumor vaccines, all are developed treatment except:
A. Adoptive transfer of tumor-specific T cells with or without interleukin 2
B. Adoptive transfer of activated cytotoxic T cells specific for tumor antigens
C. Vaccination with virus-like particles (VLPs) assembled from recombinant HPV coat proteins
D. Vaccination with dendritic cells loaded with tumor antigens
E. Vaccination with tumor cells expressing co-stimulatory molecules and IL-2
C
Primary/congenital immunodeficiency results in defects in?
B and T-cell Maturation and Activation
Hyper IgM Syndromes are X linked or Y linked?
what is defective?
it is a result of mutations in?
X linked
T helper cell mediated B cells
CD40L
HIV destroys what cells which are important for?
CD4: help coordinate the immune response by stimulating other immune cells, such as macrophages, B lymphocytes (B cells), and CD8 T lymphocytes (CD8 cells), to fight infection
