Salmonella Flashcards

1
Q

What is the only salmonella enterica to cause illness in humans

A

Salmonella enterica subsp. enterica

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2
Q

What are the serovars of salmonella enterica subsp. enterica based on

A

Somatic, flagellar, and capsular antigens

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3
Q

What are the two serovars most commonly associated with foodborne illness

A

Typhimurium and enteritidis

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4
Q

How do you serotype salmonella

A

Used to be done through reactions with antisera, now based on whole genome sequencing

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5
Q

How are salmonella serovars generally named

A

By their geographic origin

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6
Q

How can S enteritidis be transmitted

A

It can infect the ovaries of poultry and can be transmitted through eggs and undercooked poultry

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7
Q

What cells does salmonella infect

A

Phagocytic intestinal cells (M cells and dendritic cells) and non-phagocytic epithelial cells

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8
Q

What SPI’s encode adhesions needed for salmonella infect

A

SPI-3 and SPI-4

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9
Q

What does SPI-3 encode

A

MisL - binds to fibronectin on epithelial cells

MgtCB - involved in intramacrophage survival

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10
Q

What does SPI-4 encode

A

SiiE - mediates attachment to epithelial cells

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11
Q

What is a T3SS

A

A protein appendage found in gram negative bacteria

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12
Q

Pyroptosis

A

Highly inflammatory form of programmed cell death that occurs upon infection with intracellular pathogens

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13
Q

What does SPI-5 encode and what are their functions

A

SopE, SopE2, SigD

Lead to cytoskeletal remodeling and induction of proinflammatory response

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14
Q

Typhoid strains examples

A

Thypi and paratyphi

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15
Q

Non-typhoid strain examples

A

Thyphimurium, enteriditis

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16
Q

Typhoid host specificity

A

Human

17
Q

Non-typhoid host specificity

A

Broad range

18
Q

Typhoid symptoms

A

Enteric fever, adb pain, rash on trunk

19
Q

Non-typhoid symptoms

A

Gastroenteritis, adb pain, vomiting, inflammatory diarrhea

20
Q

How does ser Typhi infection lead to systemic spread

A

Uses immune cells to traffic to the lymphatic system where they hide and shed for a long period