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Pathology > Images In Pathology > Flashcards

Images In Pathology Flashcards

0
Q

Encapsulated

A

Surrounded by a fibrous capsule

Appearance
Thick pink border surrounds
the lesion

Ex
Follicular adenoma,thyroid

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1
Q

Circumscribed

A

Well-delineated lesion

Appearance
Well-defined border between
normal tissue and the lesion

Example
Fibroadenoma

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2
Q

Infiltrative

A

Invading into and among the surrounding normal cells

Appearance : Poorly defined border with normal tissue

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3
Q

Lobular

A

Circumscribed or grouped architecture

Appearance : Circumscribed, rounded
nodules of cells, simulates a normal anatomic unit

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4
Q

Pushing border

A

Circumscribed, rounded
nodules of cells, simulates a normal anatomic unit

Appearance : Can create the appearance of a capsule

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5
Q

Serpiginous Border

A

Winding snake like

Appearance : irregular , curving

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6
Q

Cellularity of a lesion - what does a lesion with hypercellularity look like

A

Tissue that is more cellular than the normal for that site (hypercellular) often looks ‘blue’ since there are more nuclei packed into a given area and nuclei stain blue on H and E.

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7
Q

What some of the possible causes the blue-ish appearance in cells that’s are hypercellular

A
  • Inflammation – influx of neutrophils (mainly seen in acute inflammation) or lymphocytes (characteristic of chronic inflammation)
  • Presence of lymphoid tissue – lymphocytes have very little cytoplasm on H and E so they always look blue
  • Tissue Repair in an early stage – granulation tissue – recently formed, quickly growing, very vascular tissue with inflammatory cells and nuclei of fibroblasts that are about to start making collagen
  • Neoplasm – Many neoplasms (usually seen as ‘tumors’) are hypercellular compared to the tissue normally seen in that site. Since increased nuclear to cytoplasmic ratio is a characteristic of malignant cells, most malignancies appear as a very blue lesion on H and E.
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8
Q

Alveolar

A

Define: In little sacs or nests

Appearance :Nested structure

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9
Q

Biphasic

A

Define :Having components of two cell

appearance: Spindled cells with islands of lineages

glands

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10
Q

Bosselsted

A

Define: Having bumps that stick out

Appearance: Rounded Probuterances

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11
Q

Cribiform

A

Define: Perforated, like a collander

Appearance: Well-formed holes within a glandular lumen

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12
Q

Discohesive

A

Define: Falling apart into single cells
Appearance: No common borders among cells

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13
Q

Eburnated

A

Like ivory

Appearance : polished, shiny surface

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14
Q

Epithelioid

A

Define: round to oval cells with lots of cytoplasm
Appearance: cells look plump ( opposite is ‘sarcomatoid’)

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15
Q

Fascicular

A

Define : composed of fascicles

Appearance: bundles of elongated spindly cells streaming in polarized arrays

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16
Q

Friable

A

Soft and falling apart

Crumbly

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17
Q

Glandular

A

Forming gland structures with
lumens

True glands have polarized cells radiating around a
lumen

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18
Q

Herringbone

A

Resembling a pattern of tweed fabric

Varying of fasicular that shows bundles alternating in a zig-zag array

19
Q

Hobnailed

A

Resembling a large headed nail used for shoes

Epithelial or endothelial cells round up and protrude into the lumen as little nails

20
Q

Indian file

A

Cells infiltrate through the tissue in single file lines

Lines may be only 3-4 cells long

21
Q

Micropapillary

A

Papillary- shaped epithelial projections without true fibrovascular cores

Can have a medusa head appearance ( serious carcinoma )

22
Q

Pagetoid spread

A

Single malignant cells scattered throughout a benign epidermis

Cells stand out at low power not belonging in the epithelium

23
Q

Palisading

A

Resembling a fence made of sharp stakes

Parallel arrays of nuclei that catch your eye at low power as a dark border

24
Q

Papyraceus

A

Parchment - like

25
Q

Papillary

A

Exophytic growth patten with fibrovascular cores supporting proliferative epithelium

Cauliflower or coral shaped structures with branching fibrovascular cores

26
Q

Pedunculated

A

With a stalk

27
Q

Polarized

A

Epithelial cells with a uniform
nuclear position, either apical
(lumen side) or basal
(basement membrane side)

Polarized cells surrounding a true lumen should show a
distinct halo of cytoplasm surrounding the lumen, if the nuclei are basal

28
Q

Reticular

A

Resembling a network or net-like array

Microcystic or honeycomb appearance

29
Q

Rosettes

A

Group of nonepithelial cells that are clustered and crowned around a common center

Pseudorosettes form around a vessel, true rosettes form around a lumen or fibrillary core

30
Q

Sessile

A

Attached directly to the base, no stalk

31
Q

Spindled

A

Composed of elongated cells with fusiform nuceli

Sheets or fascicles of fusiform cells, suggests a lesion is either a soft tissue neoplasm or a sarcomatoid variant of something else

32
Q

Storiform

A

Having a cartwheel pattern - spindle cells with elongated nuclei radiating from a center point

Cellular spindles lesion with whorls of cells as opposed to parallel fascicles or right angle bundles

33
Q

Syncytial

A

Having a cytoplasmic continuity between the constituent cells

Looks like a collection of nuclei without recognizable cell borders

34
Q

Trabecular

A

In cord-like arrays separated by fibrous septa

Long nests and cords of cell groups

35
Q

Amphophilic

A

Having affinity for both acid and basic dyes

Has an unique character, almost an iridescent purple

36
Q

Foamy macrophages

A

Macrophages stuffed with lipids

Macrophages with small dark eccentric nucleus, lipid vacuoles have granular appearance

37
Q

Granular

A

Containing granules or tiny vacuoles

Granular texture

38
Q

Keratinized

A

Keratin- producing

Very pink and dense appearance on H and E stain

39
Q

Mucous

A

Mucinous or producing mucin, AKA colloid

Mucin looks clear after processing but can be stained with mucicarmine or PAS

40
Q

Oncocytic

A

Large cells with granular eosinophilic cytoplasm, due to lots of mitochondria

Oncocytes are usually cytoplogically bland ( uniform, small, dense nuclei) and look pink on H and E

41
Q

Plasmacytoid

A

Like plasma cells

Round cells with abundant cytoplasm and an eccentric round nucleus

42
Q

Signet ring

A

Having the shape of a ring with a flattened nucleus compressed by a cytoplasm stuffed with mucin

Can be hard to see ,see on low power as non- Specific pink material in the lamina propria

43
Q

Clock face

A

Evenly distributed and clumped chromatin

Looks like we soccer ball

44
Q

Molding

A

Nuclei that press together and indent each other due to the near- absence of cytoplasm

Mosaic like appearance

45
Q

Neuroendocrine

A

Having finely speckled or salt and pepper nuceli

Nuclei are round without nucleoli, speckled

Pathology (12 decks)

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