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Hematology > Introduction > Flashcards

Introduction Flashcards

1
Q

Composition of blood

A

Plasma - 55%
Red blood cells - 45%
Buffy coat - <1%

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2
Q

Buffy coat composition

A

WBC

Platelets

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3
Q

Composition of plasma

A 
Proteins (albumin, fibrinogen, globulin)
Electrolytes
Gases
Metabolic products and wastes 
Hormones
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4
Q

Cellular components of blood

A

Red cells
White cells (neutrophils, monocytes, eosinophils, lymphocytes, basophils )
Platelets

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5
Q

What is haemopoeisis

A

Formation of blood cells (red cells, white cells, platelets)

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6
Q

When does hemopoeisis starts

A

In utero

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7
Q

Site of hematopoeisis from 0-2months

A

Yolk sac

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8
Q

Site of hemopoeisis from 2-7 months

A

Liver and spleen

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9
Q

Site of hemopoeisis 5-9 months

A

Bone marrow

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10
Q

Main organs involved in hematopoeitic cell maturation

A

Bone marrow
Thymus
Spleen
Lymph nodes

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11
Q

How can you observe development of indivuald blood cells

A

Bone marrow sampling

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12
Q

What are the two ways to do bone marrow sampling

A

Aspiration

Trephine biopsy

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13
Q

Where on body do you do bone marrow aspiration

A

Back , iliac crest

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14
Q

What are the requirements for cells growth in bone marrow

A

Building blocks
Growth factors
Cell signaling
Metabolic processes

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15
Q

Main growth factor for erythropoeisis

A

Erythropoietin

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16
Q

Main growth factor for granulocytes and monocytes synthesis

A

Granulocyte monocyte colony stimulating factor
IL-5 for eosinophils
M-CSF for monocytes
G-CSF for neutrophils

17
Q

Growth factor for lymphoid cells

A

IL-7

18
Q

Megakaryocytes growth factors

A

Thrombopoietin

Hematology (24 decks)

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