ANTIVIRAL MEDS PHARMACOLOGY Flashcards
what is aciclovirs moa?
Acyclovir is converted to its triphosphate form, acyclovir triphosphate, which competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates the viral DNA polymerase.
what is aciclovirs moa?
Acyclovir is converted to its triphosphate form, acyclovir triphosphate (ACV-TP), which competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates the viral DNA polymerase.
what is aciclovirs moa?
its converted to aciclovir triphosphate through a series of reactions and this competeitvely inhibits viral DNA polymerase and incorporates itself into DNA, acting as a termination signal
what is aciclovir indicated for?
herpes simplex viruses
how does amantadine work?
it inhibits the viral protein M2 which is needed for the viral particle to become uncoated once taken inside the cell by endocytosis
what are the indications of amantadine?
parkinsons
post herpatic neuralgia
influenza A
fatigue in MS
how does amprenavir work?
it inhibits HIV-1 protease which results in the formation of immature non-infectious viral particles
what are the indicatons for amprenavir?
HIV
how does zidovudine work?
once activated to zidovudine triphosphate it is a structural analog of thymidine and so comoetes for incorporation into viral DNA, inhibiting reverse transcriptase
what are the indications of zidovudine?
HIV
what are the classes of antivirals?
attachment inhibitors, entry inhibitors, uncoating inhibitors, protease inhibitors, polymerase inhibitors, nucleoside and nucleotide reverse transcriptase inhibitors, nonnucleoside reverse-transcriptase inhibitors, and integrase inhibitors
whats the main antiviral class used for influenza?
neuraminidase inhibitors
such as zanamivir and oseltamivir
what type of antiviral is zanamivir?
a neuramindase inhibitor
what class of antiviral is zanamivir?
neuraminiase inhibitor
