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MICROBIOLOGY 2.0 > Spore Forming > Flashcards

Spore Forming Flashcards

0
Q

Non motile, aerobic, spore forming

A

Bacillus

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1
Q

Rods in chains with square ends and spore at the center

A

Bacillus sp

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2
Q

Anaerobic, motile (f), toxin mediated

A

Clostridium

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3
Q

1st dse attributed to a bacterium

A

B anthracis

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4
Q

1st bacterial disease prevented by vaccination

A

B anthracis

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5
Q

This sp shows no hemolysis

A

B anthracis
C tetani
C botulinum

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6
Q

This sp shows hemolysis

A

B cereus

C perfringens

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7
Q

Liquifies gelatin

A

Bacillus

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8
Q

C tetani causes systemic invasion

A

False. Localized

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9
Q

C tetani causes the s/sx

A

No, toxin mediated

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10
Q

Mode of migration of tetanospasmin

A

Retrograde migration

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11
Q

What enzyme does tetanospamin degrades that prevents docking of vesicles

A

Synaptobrevin

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12
Q

What produces tetanospamin

A

Vegetative c tetani

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13
Q

What nts does tetanospamin block

A

Gaba and glycine

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14
Q

True or false. Small amount of tetanospasmin is not lethal. Requires large amount.

A

False

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15
Q

Target of tetanospasmin

A

Anterior horn cells

BS

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16
Q

What aids in spore germination and toxin prod

A

Low redox potential

Calcium salts
Necrotic tissue
Asso pyogenic infxns

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17
Q

Tetanus has CNS manifestations like altered LOC

A

None, fully conscious

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18
Q

Trismus

A

Contraction of jaw muscles

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19
Q

Risus sardonicus

A

Contraction of facial muscle

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20
Q

Test to check for trismus and risus

A

Spatula test

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21
Q

Cod in tetanus

A

Respi muscle arrest

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22
Q

IP for tetanus

A

4-5 days even weeks (jawetz)

average 14 (lecture)

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23
Q

Strychnine poisoning

A

Used for ddx in tetanus

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24
Q

Antimicrobials for tetanus

A

Pen G

Metro

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25
Q

What organism has their spore centrally located

A

Bacillus

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26
Q

The’re spores are usually larger than the rod itself. Located terminally

A

Clostridium

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27
Q

Most powerful neurotoxin

A

Botulinum toxin

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28
Q

Affects primarily the cranial nerves thus PNS

A

Botulinum toxin

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29
Q

Proteolysis of SNARE proteins

A

Synaptobrevin
Syntaxin
Snap 25

Botulinum toxin

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30
Q

Toxin A and B

A

Adult

Canned goods 1-2 days

31
Q

Toxin E and F

A

Infant
3-30 days
Honey

32
Q

GI sx not prominent

NO FEVER

A

Botulism

33
Q

What toxin causes floppy baby syndrome

A

Toxin e and F

34
Q

Do patients who recovered from botulism will develop antitoxin thereafter?

A

NO. Susceptible ulit

35
Q

Diagnosis of botulism

A

Passive hemaglutination

Radioimmunoassay

36
Q

To what age group is stool exam useful for dx of botulism

A

Infants only and not in serum

37
Q

Do antimicrobials have effect on botulism

A

None

38
Q

This org has virulence factor of theta toxin alpha and DNAse and hyaluronidase

A

C perfringes

39
Q

Characterized with hemolysis thus causing anemia

A

C perfringes

40
Q

Presents with fever

A

Perfringes

Difficile

41
Q

How can lecithinase activity be seen

A

Precipitate formation around egg yolk media

42
Q

What do u call the rxn in lecithinase activity

A

Nagler rxn

43
Q

What sp is associated with antibiotic induced proliferation

A

C difficile

44
Q

Difficile produces fever?

A

True

45
Q

What abx usually cause c difficle

A

FAC u difficle
FLUORO
AMPI
CLINDA

46
Q

Tx for difficle

A

Dc of offending abx

Give metro or vanco

47
Q

Which clostridium sp has a double zone of hemolysis

A

C perfringess

48
Q

Has large raised colonies

A

Perfringens

49
Q

Presence of intestinal pseudomembranes

A

C difficle

50
Q

Has large rectangular spores

A

Perf

51
Q

Has squash racket spore

A

Tetani

52
Q

Has oval subterminal spore one is bigger

A 
C botulinum
C difficile (larger)
53
Q

Botulinum is heat labile

A

True

54
Q

What bacillus produces enteroroxin

A

Cereus

55
Q

Which bacillus has vaccine

A

Anthracis

56
Q

Which bacillus is capsulated

A

Anthracis

57
Q

Which bacillus is motile

A

Cereus

58
Q

Which bacillua is hemolytic

A

Cereus

59
Q

Which bacilli has medusa head

A

Anthracis

60
Q

Which is bamboo cane like

A

Anthracis

61
Q

Which bacillus has whipped egg white

A

Anthracis

62
Q

Which bacillus has lecithinase

A

Cereus

63
Q

What causes virulence in anthracis

A

Poly d glutamic acid capsule

Anthrax toxin

64
Q

Which comes from Pxo2

A

Capsule

65
Q

From pxo1

A

Toxin

66
Q

Abx are effective in vegetative forms and even spores

A

False. Not in spores

67
Q

Only respi anthrax has delayed onset

A

True

68
Q

Time when eschar is fully developed

A

After 7-10 days

69
Q

This type of anthrax leads to meningitis

A

Cutaneous and inhalataion

70
Q

Ciprofloxacin

A

Doc for cutaneous anthrax

71
Q

Doc for endemi anthrax

A

Pen G

72
Q

Doc for cereus

A

Vancomycin

73
Q

Doc for cereus immunocom

A

Penicillin

74
Q

Are bacillus aerobe?

A

Yes

75
Q

Are clostridium anaerobe

A

Yes

MICROBIOLOGY 2.0 (7 decks)

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