Gout Flashcards
1
Q
Colochicine
A
Mechanism of Action:
- binds to tubulin
- inhibits polymerization & microtubule formation
- disrupts cellular functions
- blocks cell division disrupting mitotic spindle
- inhibits synthesis & leukotriene release
Adverse:
- nausea
- vomiting
- abdominal pain
- diarrhea
- myopathy
- neutropenia
- aplastic anemia
- alopecia
Contraindications:
- pregnancy
- hepatic disease
- renal disease
- cardiovascular disease
2
Q
Allopurinol
A
First-line uric acid-lowering therapy
Purine analog
Mechanism of Action:
- dec. uric acid production competitively xanthine oxidase
Co-administered w/NSAID or colchicine
Adverse:
- hypersensitivity
- skin rashes
- Steven-Johnson syndrome (discontinue)
Contraindications:
- mercaptopurine
- azathioprine
3
Q
Febuxostat
A
Adverse:
- hypersensitivity
- skin rashes
- Steven-Johnson syndrome (discontinue)
Contraindications:
- mercaptopurine
- azathioprine
4
Q
Probenecid
Losartan
Fenofibrate
A
Increase uric acid secretion
Mechanism of Action:
- inhibit URAT1
Adverse:
- peptic ulcers
- hypersensitivity reactions
- renal stones
Contraindications:
- patients w/nephrolithiasis
- low dose aspirin
