Mycology Flashcards

1
Q

what are fungi

A

eukaryotic organisms with chitin cell walls and ergosterol plasma membranes

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2
Q

what are yeasts, name some examples

A

single cellular fungi that bud to replicate e.g. candida, cryptococcus and histoplasma

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3
Q

what are moulds and name some examples

A

multicellular hyphae that grow by branching. e.g. dermatophytes, aspergillus, agents of mucormycoses

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4
Q

what is the most common cause of fungal infection in humans

A

candida

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5
Q

Treatment for oral thrush

A

nystatin

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6
Q

treatment for vulvovaginitis

A

fluconazole oral or cotrimazole topical

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7
Q

Investigations for disseminated candida

A

imaging, serology for beta D glucan, ECHO, fundoscopy

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8
Q

management of disseminated candida

A

2 weeks+ antifundals e.g. echinocandin

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9
Q

cryptococcosis serotypes a+D, vs serotypes B+C

A

A+d cryptococcus neoformans In immunocompromised, b+C cryptococcus gattii in immunocompetant

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10
Q

which animal is cryptococcus associated with

A

pigeons

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11
Q

risk factors for cryptococcus

A

impaired t cell immunity

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12
Q

cryptococcus gattii

A

causes meningitis in immunocompetent individuals in tropical latitudes, high incidence of SOL in brain and lung

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13
Q

what type of ink is used for cryptococcal stain

A

india ink

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14
Q

Cryptococcus management

A

induction (amphotericin), consolidation (fluconazole) and maintenance, repeat LP

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15
Q

Pneumocytis jirocerci

A

ubiquitus aspergillus

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16
Q

why might antifungals not work in PCP

A

lacks ergosterol in wall

17
Q

What kind of patients does mucormycoses favour

A

diabetic

18
Q

how do azoles work

A

inhibiting the conversion of lanosterol to ergosterol (14 a demethylase)

19
Q

how do polyenes work

A

binds sterols in membrane causing electrolyte leakage

20
Q

echinocandins

A

interfere with fungal cell wall synthesis