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MICROBIOLOGIE > streptocoque pyogenes (APE 1) > Flashcards

streptocoque pyogenes (APE 1) Flashcards

1
Q

réservoir

A

humain : oropharynx & peau

arthropodes

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2
Q

transmission

A

gouttelettes
contact dermique direct
indirect avec fomite
vecteurs => arthropodes

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3
Q

facteurs de risque

A
  • 2-15 ans
  • objet brise barrière cutanée, brèche dans la peau
  • crowds (classes, garderies)
  • hiver
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4
Q

facteurs de virulence physique & chimique

A

Prot M
C5a peptidase
capsule acide hyaluronique

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5
Q

Prot M

A

inhibe C3b => nécessaire pour phagocytose

& invasion ¢

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6
Q

C5a peptidase

A

inhibe C5a => chimiokine
phagocyte neutrophile
échapper à la phagocytose

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7
Q

capsule acide hyaluronique

A

résistance physique

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8
Q

facteurs de virulence: adhérence tissus de l’hôte

A

Prot M
Prot F
acide lipotéichoïque

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9
Q

Prot F

A

invasion ¢

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10
Q

facteurs de virulence enzymatiques

A

Peptidase C5a
Streptokinases A & B
DNase A à D

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11
Q

Streptokinases A & B

A

clive fibrine & fibrinogènes
=> lyse caillots, dépôts fibrine
=> facilite diffusion

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12
Q

DNase A à D

A

rend pus visqueux

facilite diffusion du patho

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13
Q

facteurs de virulences toxines

A
  • Exotoxine pyrogène Spe A/B/C/F

- Streptolysine S

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14
Q

Exotoxine pyrogène

A

Superantigène érythrogène

  • sensible chaleur
  • relargage cytokines pro-inflammatoires (interaction CD4 & macrophages)
  • fasciite nécrosante
  • strep TSS
  • fièvre scarlatine
  • rash
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15
Q

Streptolysine S

A

lyse GR, GB, plaquettes & phagocytes

- B-hémolyse !

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16
Q

Streptolysine O

A

lyse GR, GB, plaquettes & phagocytes

  • B-hémolyse
  • oxygène-labile
  • inhibée par cholestérol lipides peau
17
Q

facteurs virulence par invasion des ¢ épithéliales

A

Prot M

Prot F

18
Q

maladies suppuratives

A
  • pharyngite
  • impetigo
  • fasciite nécrosante => mangeuse de chaire
  • S. choc toxique streptococcique
  • Scarlatine
  • Cellulite
19
Q

maladies non suppuratives

A
  • fièvre rhumatismale: rhumatisme articulaire aigu

- glomérulonéphrite aiguë

20
Q

rhumatisme articulaire aigu

A

JONES
Joint: articulations gonflées
O: coeur: atteinte cardiaque valve mitrale
N: nodules peau
E: érythème marginé (serpentins rouges peau)
S: sydenham chorea

21
Q

ATB pour infections suppuratives

A

Péniciline

MICROBIOLOGIE (31 decks)

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