Tranexamic acid

Question 1

Indications - tranexamic acid

Answer 1

❑ Bleeding within 3 hours of injury and presenting at any point with HR greater than 110 bpm or systolic BP less than 90 mmHg. Ex. TBI, Post-Partum hemorrhage, significant traumatic injury with internal bleeding.

Question 2

Dosage - tranexamic acid

Answer 2

(>16 years old): 1 g IV/IO dilute in 250 mL D5W or 100ml Normal Saline bag and infuse over 10 minutes; followed by as soon as practical an infusion of 1 g over 8 hours

(<16 years old): 15mg/kg IV/IO to a max of 1g over 10 minutes. Follow bolus dose with 2mg/kg/hr IV/IO to a max of 1g over 8 hours.

Question 3

Contraindications - tranexamic acid

Answer 3

❑ Hypersensitivity to Tranexamic Acid
❑ Active thromboembolic disease ( pulmonary embolus, DVT or stroke)
❑ Unable to initiate bolus within 3 hrs of injury onset
❑ GI Bleeds

Question 4

What is the drip rate for tranexamic acid using a 10gtt?

Answer 4

To infuse 250 mL over 10 minutes the drip rate is 4 gtts/sec using a 10 gtt set