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My NAPLEX > Oncology 1 > Flashcards

Oncology 1 Flashcards

1
Q

Dosing Consideration for Select Highly Toxic Drugs

A

Bleomycin - lifetime cumulative dose 400 units = pulmonary toxicity
Doxorubicin - lifetime cumulative dose 450-550 mg = cardiotoxicity
Cisplatin - dose per cycle not to exceed 100 mg = nephrotoxicity
Vincristine - single dose “capped” at 2 mg = neuropathy

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2
Q

Dexrazoxane

A

Zinecard - prophylaxis to prevent cardiomyopathy

Totect - treatment for extravasation

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3
Q

Filgrastim

A

Neuopogen

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4
Q

Pegfilgrastim

A

Neulasta

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5
Q

Epoetin alfa

A

Epogen, Procrit

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6
Q

Darbepoetin alfa

A

Aranesp

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7
Q

Aprepitant

A

Emend - capsule, suspension, injection

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8
Q

Fosaprepitant

A

Emend - Injection

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9
Q

Ondansetron

A

Zofran, Zuplenz film

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10
Q

Granisetron

A

Sancuso

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11
Q

Palonosetron

A

Aloxi

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12
Q

Dexamethasone

A

Decadron

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13
Q

Prochlorperazine

A

Compazine

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14
Q

Promethazine

A

Phenergan - do not use in children < 2 years; do not give via intra-arterial or SC administration; IV route can cause serious tissue injury if extravasation occurs

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15
Q

Metochlopramide

A

Reglan - tardive dyskinesia that can be irreversible

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16
Q

Olanzapine

A

Zyprexa

17
Q

Dronabinol

A

Marinol
Capsules: C-III
Solution: C-II
Refrigerate

18
Q

Nabilone

A

Cesamet

C-II

19
Q

Lorazepam

A

Ativan

C-IV

20
Q

Myelosuppression

A

Almost all classic chemotherapy drugs, except:

Asparaginase, bleomycin, vincristine

21
Q

Nausea and vomiting

A

Cisplatin, cyclophosphamide, ifosfamide

22
Q

Mucositis

A

Fluorouracil and methotrexate

23
Q

Diarrhea

A

Irinotecan, capecitabine, fluorouracil and methotrexate

24
Q

Constipation

A

Vincristine

25
Q

Xerostomia

A

Caused by radiation therapy to the head or neck regions

26
Q

Cardiotoxicity

A

Cardiomyopathy: anthracyclines

QT prolongation: arsenic trioxide, many TKIs

27
Q

Pulmonary Toxicity

A

Pulmonary fibrosis: bleomycin, busulfan, carmustine, lomustine
Pneumonitis: immune therapy MAbs

28
Q

Hepatotoxicity

A

Antiandrogens (bicalutamide, flutamide, nilutamide)

29
Q

Nephrotoxicity

A

Cisplatin, methotrexate

30
Q

Hemorrhagic cystitis

A

Ifosfamide (all doses), cyclophosphamide (higher doses)

31
Q

Neuropathy

A

Vinca alkaloids, platinum, taxanes

32
Q

Thromboembolic risk

A

Aromatase inhibitors (anastrozole, letrozole) SERMs (tamoxifen, raloxifene)

My NAPLEX (8 decks)

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