Hps Flashcards
1
Q
What is hps
A
Hps is a liver induced pulmonary vascular disorder characterized by widened alveolar arterial oxygen gradient
2
Q
What is pathogenesis
A
Angiogenesis
No and endothelin- increased production and dec metabolism
Intrapulmonary vd
V/q mismatch, a-a gradient, shunt
3
Q
Features
A
Platypnoea
Orthodeoxia 5% or 4mmhg fall on standing
4
Q
Signs
A
Spider angioma
Clubbing
Peripheral cyanosis
5
Q
Diagnostic criteria
A
1)cirrhosis /portal htn
Inc aa gradient >15
Ipvd on bubble echo
6
Q
Rx
A
O2
Tx
Pentoxyphilline - interferes in tnf alpha synthesis
