Pulmonary Aspergillosis

Question 1

Species

Answer 1

A.fumigatus
Niger
Flavus

Question 2

Spectrum

Answer 2

Simple colonization
Hsn rxn
Saprophytic growth
Invasive infection

Question 3

Hsn reaction

Answer 3

Abpa
Bronchocentric granulomatosis
Extrinsic allergic alveoloitis
Allergic bronchial asthma

Question 4

Invasive infection

Answer 4

Invasive bronchial aspergillosis
Bronchial stump aspergillosis
Invasive pulmonary
Chronic pulmonary aspergillosis 
Ccpa
Cnpa
Cfpa

Question 5

Aspergilloma classification

Answer 5

Primary - proliferation leads to cavity

Sec- growth in cavity/cyst

Question 6

C/f

Answer 6

Hemoptysis

Question 7

Xray

Answer 7

Monods sign
Air crescent sign
Tilt test

Question 8

Diagnosis of aspergilloma

Answer 8

Radio
Skin test
Culture
Ab to a.fumigatus
Gms stain

Question 9

Mx of aspergilloma

Answer 9

Surgical
Intracavitary antifungal amph-b , ketoconazole
Bae
Itraconazole 200- 400 day for 6 to 18 months
Vori if itra resistant

Question 10

Ipa r/f

Pathogenesis

Answer 10

Lynphophenia
Global dysregulatioj of th1/2
Aspergillus mediated suppression of host th1 by gliotoxin
Proliferation

Question 11

Diagnosis

Answer 11

Halo sign
Air cresrnt sign
Bal/biopsy- hpe, culture/ stain
Galactomannan - blood and bal
1,3 beta d glucan- fp in cirrhosis/hd
Pcr

Question 12

Rx

Answer 12

Vori- 6mg bd 1day
4mg bd till improvement
Oral 200 bd

Liposomal- 3-5mg/kg

Question 13

Salvage therapy

Answer 13

Caspo/posoconazole

Question 14

When do u do sx

Answer 14

Pulm Infarction

Pul tissue sequestration not respondung to abx

Question 15

Prophylaxis in whom n what

Answer 15

Posoconazole doc.200 mg qid with soda
Vori
In high risk transplant, neutropenic