Kidd Antibodies

Question 1

What kind of antibodies are Kidd antibodies?

Answer 1

IgG, react STRONGER with enzyme treated cells.

They are NOT naturally occurring; they are produced from transfusion or pregnancy.

Question 2

What makes Kidd antibodies unique compared to other antibodies?

Answer 2

Kidd antibodies can cause DELAYED transfusion rxns (Kidds are delayed)

and they can cause intra AND extravascular hemolysis

Question 3

What happens in antibody titers with patients who have Kidd antibodies?

Answer 3

The titers rise and fall rapidly

Question 4

While ABO, Rh, Kell, Duffy, Kidd, SsU are clinically significant, which of the following antibodies generally react at only the Coombs phase (also known as Antihuman Globulin phase)?

Answer 4

Kidd, Duffy, Kell

Question 5

What happens to red blood cells that lack Kidd antigens in 2M urea?

Answer 5

They are resistant to lysis.

Kidd antigens are located on the red cell urea transporter. Red cells that lack Kidd antigens resist lysis by 2M urea.

Question 5

What happens to red blood cells that lack Kidd antigens in 2M urea?

Answer 5

They are resistant to lysis.

Kidd antigens are located on the red cell urea transporter. Red cells that lack Kidd antigens resist lysis by 2M urea.

Question 6

Kidd antigens show dosage. Would the antibody-antigen reaction strength be greater if the antigens were homozygous or heterozygous?

Answer 6

Greater reaction strength in the homozygous state because there is double dose of the antigen on the surface of the RBC.

Question 7

Antibodies within what blood group system are known to result in severe hemolytic transfusion reactions, but are not always detected during pre-transfusion testing in the blood bank?

Answer 7

Kidd.

This is because Kidd antibody titers rise and fall rapidly, making them undetectable even after several months after exposure to the antigen.