Duffy Antibodies

Question 1

What kind of antibodies are Duffy antibodies?

Answer 1

IgG, clinically significant

May show dosage

Question 2

Are Duffy antibodies enhanced with enzymes?

Answer 2

No. Negative rxn with enzyme treated cells

Question 3

Are Duffy antigens destroyed by enzymes?

Answer 3

YES. (Duffy the vampire destroys his M&Ns)

Question 4

68% of African Americans have this Duffy phenotype.

Answer 4

Fy(a-b-) or FyFy

This genotype is known to confer resistant to P. vivax (malaria) merozoites!

Question 5

What percentage of African Americans have the Duffy phenotype Fy(a-b-) or Fyfy?

Answer 5

68%

This genotype is known to confer resistant to P. vivax (malaria) merozoites!

Question 6

What Duffy blood group system genotype is known to confer resistant to P. vivax (malaria) merozoites?

Answer 6

Fy(a-b-)

The correct answer is Fy(a-b-). In the mid-70s, it was observed that Duffy (Fy) (a-b-) RBCs resist infection by Plasmodium knowlesi and Plasmodium vivax. This provides an explanation for the high frequency of Fy(a-b-) persons originating from West Africa.

Question 7

Anti-Fy3 is a rare Duffy antibody created by individuals with what Duffy genotype?

Answer 7

Fy(a-b-)

This rarely encountered immune antibody reacts with all red blood cells except those of the Fy(a-b-) phenotype. Anti-Fy3 is a rare antibody produced by Fy(a-b-) individuals lacking the Duffy glycoprotein.