Lung Carcinoma Flashcards
~ MOST FREQUENTLY diagnosed major CANCER in the world
~ MOST COMMON cause of CANCER MORTALITY
LUNG CARCINOMA
RISK FACTORS of Lung CA
SMOKING
Industrialized hazards (Asbestos, Arsenic, Nickel etc)
Air pollution (SECONDHAND SMOKE)
Acquired mutations
MOST COMMON LUNG CA
ADENOCARCINOMA
2 — Squamous cell
3 — Small cell
Derived from KULCHITSKY cells
SMALL CELL
Site: PERIPHERAL
ADENOCARCINOMA
Site: CENTRAL/Hilar
SQUAMOUS CELL
Mnemonics: PA CS
PERIPHERAL – Adenocarcinoma
Central — Squamous cell
Most common type in NEVER smokers
Adenocarcinoma
Associated with tobacco smoke: ALMOST ALWAYS
SMALL CELL
Morphology:
~ GLANDULAR differentiation
~ MUCIN production
ADENOCARCINOMA
Morphology:
~ KERATINIZATION
~ INTERCELLULAR BRIDGES
SQUAMOUS CELL
Morphology:
~ (+) NUCLEAR MOLDING
~ SALT and PEPPER chromatin
~ HIGH mitosis
~ (+) AZZOPARDI effect
SMALL CELL
AZZOPARDI EFFECT: basophilic staining of vascular walls
MOST AGGRESSIVE LUNG CA
SMALL CELL CA
