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PHM 701- Alcohol, Seizures, Substance Abuse, Schizophrenia, Depression > SNRIs > Flashcards

SNRIs Flashcards

1
Q

Desvenlafaxine indication

A

MDD

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2
Q

Side effects of desvenlafaxine

A

HLD, seizures, eosinophilic pneumonia

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3
Q

Desvenlafaxine has interactions with what enzyme?

A

3A4

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4
Q

Venlafaxine indications

A

MDD, GAD, panic disorder, social phobias

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5
Q

Venlafaxine side effects

A

BP changes at higher doses, eosinophilic pneumonia

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6
Q

Counseling point for venlafaxine

A

Take with food

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7
Q

Venlafaxine as interactions with what enzyme?

A

2D6

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8
Q

Duloxetine indications

A

MDD, GAD, fibromyalgia, musculoskeletal and neuropathic pain

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9
Q

Duloxetine side effects

A

Potential hepatotoxicity, severe skin reactions, small increase in FBG, urinary retention, orthostatic hypotension

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10
Q

What may you see less of with duloxetine?

A

Less insomnia potential

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11
Q

What should you avoid when taking duloxetine?

A

ALCOHOL

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12
Q

Avoid duloxetine in what patients?

A

ESRD and liver dysfunction

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13
Q

Levomilnacipran indication

A

MDD

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14
Q

Levomilnacipran side effects

A

Urinary retention, increased heart rate

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15
Q

SNRI dosing and elderly patients

A

No dosing adjustments needed!

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16
Q

Side effects of all SNRIs

A

HTN, tachycardia and palpitations, orthostatic hypotension, N/V, constipation, urinary hesitation, risk of mania/hypomania

17
Q

Are SNRIs more energy-boosting or sedating?

A

Energy-boosting

18
Q

Watch out for this in SNRIs

A

Abnormal bleeding, increased risk of mania activation, elevated blood pressure, hyponatremia, serotonin syndrome and discontinuation syndrome, angle-closure glaucoma

19
Q

SNRIs that inhibit serotonin and NE uptake (but also weak for DA)

A

Venlafaxine, desvenlafaxine

20
Q

SNRIs that inhibit serotonin and NE uptake

A

duloxetine, levomilnacipran, minalcipran

21
Q

Agents to avoid while taking a SNRI

A

Other serotonergic agents, MAOIs, linezolid, methylene blue

PHM 701- Alcohol, Seizures, Substance Abuse, Schizophrenia, Depression (23 decks)

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