[DISCUSSION] MODULE 1 UNIT 3 ADDITIONAL NOTES

Question 1

Increased plasma and serum

Answer 1

IgG

Question 2

Immunity-conferring function of globulin fraction of the immune system

Answer 2

Immunoglobulins

Question 3

This makes immunoglobulins the third fastest migrating group of globulin

Answer 3

gamma globulins

Question 4

Specificity is based on a physical and chemical interaction between the two

Answer 4

V region

Question 5

Antibody-binding site

Answer 5

Paratope; Fab

Question 6

Extensive genetic rearrangement (scientist)

Answer 6

Tonegawa

Question 7

The promotion of phagocytosis of antigens by macrophages and neutrophils is an important factor in

Answer 7

antibacterial defenses

Question 8

Protein molecules called [?], which can bind the constant region of Ig molecules, are present on the surfaces of macrophages and neutrophils

Answer 8

Fc receptors (FcR)

Question 9

Binds the fc portion; more efficient

Answer 9

Fc receptors (FcR)

Question 10

Known opsonin
Phagocytosis

Answer 10

IgG

Question 11

Natural killer cells
Innate immune system
Kills for the release of GRANZYMES and PERFORINS

Answer 11

Large granulated lymphocytes

Question 12

can activate a collection of serum glycoproteins called the complement system via the classical pathway

Answer 12

IgM and IgG

Question 13

Compliment fixation leads to

Answer 13

1. Lysis of microbes
2. Opsonization and phagocytosis

Question 14

Lysis of microbes leads to the formation of membrane-activated complex called

Answer 14

Cascade

Question 15

Enzyme produced during opsonization and phagocytosis

Answer 15

C3 convertase

Question 16

Two fragments of c3 convertase

Answer 16

C3a
C3b

Question 17

Known fragment of c3 convertase that will lead to opsonization and phagocytosis with the addition of microbe

Answer 17

C3b

Question 18

C3, C4, C5
Degradation of basophils and mast cells = HISTAMINE (respiratory inflammatory reactions)

Answer 18

Anaphylatoxins

Question 19

This is an effector mechanism in which cells coated with antibody react with Fc receptors on natural killer cells (and other lymphocytes) to cause target cell damage

Answer 19

Antibody-Dependent Cell Mediated Cytotoxicity (ADCC)

Question 20

Binding of AG

Answer 20

Paratope

Question 21

Site of attack by enzymes

Answer 21

hinge region

Question 22

Light (L) chains

Number of variable regions
Number of constant regions
Number of domain

Answer 22

1
1
1

Question 23

Light (L) chains

Number of variable regions
Number of constant regions
Number of domain

Answer 23

1
3
4

Question 24

seen between:
o heavy chains (H-H)
o heavy chains and light chains (H-L)

Answer 24

Interchain disulfide bonds

Question 25

Within chains
Holds the domains together

Answer 25

Intrachain disulfide bonds

Question 26

this shows a wide variation in amino acid sequence in the amino or N terminal portion of the immunoglobulin molecule

Answer 26

Variable (V) Region