TRANSPLANTATION

Question 1

Pre‐existing antibodies due to either blood group incompatibility or pre-sensitization to class I MHC through blood transfusion

Answer 1

Hyperacute

Question 2

Activation of lymphocytes

Answer 2

Acute

Question 3

Multiple immune mechanisms or recurrence of the original disease

Answer 3

Chronic

Question 4

Antibodies bind to blood vessel endothelium in the graft, resulting in complement activation, neutrophil recruitment, platelet aggregation, and blood clotting

Answer 4

Hyperacute

Question 5

Cytotoxic T‐cells attack the donor cells
expressing foreign MHC. Helper T‐cells and B‐cells collaborate in the production of antibodies to alloantigens

Answer 5

Acute

Question 6

Mechanisms not fully understood. Can involve lymphocytes, phagocytes, antibodies and complement

Answer 6

Chronic

Question 7

Remove organ

Answer 7

Hyperacute

Question 8

Increase immunosuppression (with caution)

Answer 8

Acute

Question 9

Does not respond to increased
immunosuppression; replace organ

Answer 9

Chronic