Th - PET imaging microglia

Question 1

What is PET? (meaning)

Answer 1

Positron Emission Tomography

Question 2

What is molecular imaging? (explain complicated)

Answer 2

Molecular imaging is a type of medical imaging that provides detailed pictures of what is happening inside the body at the molecular, biochemical and cellular level

Question 3

What is PET? (explain complicated)

Answer 3

PET imaging is a molecular imaging technique based on detection of isotope labelled tracers and used for imaging biochemical processes sin the body

Question 4

What is microgliosis?

Answer 4

Increase of the number of microglia and their concentration in localized areas

Question 5

Where are activated microglia concentrated in MS? (2)

Answer 5

In the inflammatory active lesion and the borders of the chronic active lesions

Question 6

Where are activated microglia concentrated in Alzheimer’s?

Answer 6

In the amyloid beta plaques

Question 7

What is TSPO? (meaning)

Answer 7

Translocator protein

Question 8

Why is TSPO a good target for PET imaging in Alzheimer’s disease and MS?

Answer 8

Because it’s overexpressed on activated microglia, not on resting microglia

Question 9

(Low/high) uptake of TSPO tracer in a lesion indicates an active lesion

Answer 9

High

Question 10

(Low/high) uptake of TSPO tracer in a lesion indicates an inactive lesion

Answer 10

Low