Sulfonamides

Question 1

Sulfonamides Description

Answer 1

By-product of the dye prontosil rubrum.

Question 2

Sulfonamides Distribution

Answer 2

readily absorbed from GI tract, distributed through all body tissues, enter CSF, pleural fluid, and synovial fluid

Question 3

Sulfonamides Elimination

Answer 3

eliminated through glomerular filtration and hepatic metabolism

Question 4

Sulfonamides Mechanism of Action

Answer 4

inhibiting the incorporation of para-aminobenzoic acid, a basic building block of bacteria.

Question 5

Sulfonamides Clinical uses

Answer 5

treating ulcerative colitis, and in combination with other drugs for UTIs, pneumonia, toxoplasmosis, and resistant gram-negative infections.