PANCE_hematology 5%

Question 1

(RR)
“A 24-year-old man with HIV was recently started on trimethoprim-sulfamethoxazole. He complains of two days of worsening fatigue and dyspnea. The patient appears pale with scleral icterus. Laboratory testing shows a marked anemia and elevated total and indirect bilirubin. What is the most likely diagnosis?”

Answer 1

G6PD deficiency

Question 2

(RR)
Heinz bodies on blood smear - - think:

Answer 2

G6PD deficiency

Question 3

(RR)
MC disease-producing enzymopathy in humans

Answer 3

G6PD deficiency

Question 4

(RR)
what drugs can precipitate symptoms of G6PD?

Answer 4

TMP-SMX
and other sulfonamides

(they are oxidative)

Question 5

(RR)
G6PD protects against what infectious disease?

Answer 5

malaria

Question 6

(RR)
the result of G6PD deficiency and oxidative stress =

Answer 6

hemolytic anemia

Question 7

(RR)
G6PD is inherited via what genetic pattern?

Answer 7

it is X-linked recessive

Question 8

(RR)
G6PD pts may have a hx of taking what five things?

Answer 8

antimalarials
sulfonylureas
quinolones
nitrofurantoin
fava beans

Question 9

(RR)
MC causes of macrocytic anemia

Answer 9

Vitamin B12 (cobalamin) deficiency
folate deficiency
direct ethanol toxicity

Question 10

(RR)
lab findings of macrocytic anemia

Answer 10

MCV > 100 fl
hypersegmented neutrophils

Question 11

(RR)
at what point are platelets tranfused?

Answer 11

platelet count < 50,000 per mcL with severe active bleeding

Question 12

(NCCPA practice exam)
“Which of the following agents affects coagulation by inhibiting platelet aggregation?
a) ASA
b) heparin
c) protamine
d) Vitamin K
e) warfarin”

Answer 12

(CME)
a) ASA