Lecture 7

Question 1

Cancer is caused by combination of …… and ……. Change

Answer 1

Genetic , epigenetic

Question 2

Genes are mad up by

Answer 2

Sequence of DNA

Question 3

Genes contain…….. for making …… that express specific ……….

Answer 3

Information, protein . Traits

Question 4

DNA …. To RNA , RNA ……. mRNA , RNA ……. To protein

Answer 4

Transcribed, splicing , translocation

Question 5

Genetic change is and ……….. change to the ………. Of the ………

Answer 5

Irreversible , genetic material , tumor cell

Question 6

Epigenetic change is an …….. change

Answer 6

Reversible

Question 7

What may cause genetic change

Answer 7

Single point mutation , gross chromosomal rearrangements

Question 8

What may cause epigenetic change

Answer 8

DNA methylation, histones modification

Question 9

Type of single point mutation

Answer 9

Nonsense mutation , missense mutation , silent mutation

Question 10

Nonsense mutation cause

Answer 10

Inappropriate termination of translation

Question 11

What nonsense mutation cause to the protein

Answer 11

Shorten the protein

Question 12

What missense cause

Answer 12

Encodes different amino acid

Question 13

What missense mutation cause to the protein

Answer 13

Result in non-functional protein or hyperactive protein

Question 14

Methylated DNA can not be ……. ( and verse verse )

Answer 14

Transcribed

Question 15

What cause methylated DNA

Answer 15

DNA methyltransferase

Question 16

What cause demethylated DNA

Answer 16

DNA demethylase

Question 17

What cause histone acetylated

Answer 17

Histone acetyltransferase

Question 18

What are the two type of gene that are changed in cancer

Answer 18

Oncogenes and tumor suppressor gens ( TSG)

Question 19

Types of oncogenes

Answer 19

RAS , MYC , ABL

Question 20

Types of TSG

Answer 20

P53 , RB , BRCA1,2

Question 21

BRCA1,2 cause ?

Answer 21

Breast cancer

Question 22

To mutate oncogenes need how many mutated allel

Answer 22

One

Question 23

To get mutated TSG need how many mutated allele

Answer 23

2

Question 24

Mutation of RAS will result in not giving what

Answer 24

GTPase

Question 25

Reduction of GTPase will cause

Answer 25

Always activated RAS

Question 26

What is the kind of translocation to c-MYC that cause Burkitt’s lymphoma

Answer 26

Reciprocal translocation

Question 27

The translocation of c-MYC from which chromosome to which chromosome

Answer 27

8 to 14

Question 28

The mutation to c-MYC will stimulate

Answer 28

Cell proliferation, promot tumor formation and eventually cancer

Question 29

Li-Fraumeni syndrome caused by mutation to ?

Answer 29

P53

Question 30

The mutation to p53 cause

Answer 30

Loss of ability to stop cell cycle with damage DNA and can not do cell death for cell with Danegeld DNA

Question 31

If cell with damaged DNA continues division will lead to ?

Answer 31

Increase mutation in genome and genome instability

Question 32

Why can not do cell death with mutated p53

Answer 32

The transcription product required to do cell death is not available