Lymphoid Tissues Flashcards
Primary lymphoid tissue definition
Where lymphocytes (B/T/natural killer cells)are produced
What are the primary lymphoid organs
Thymus
Bone marrow
Foetal liver
What tissue is the primary site of hematopeisis
Bone marrow
Repertoire definition
Range of genetically different BCRs and TCRsin a given host
Where does final maturation of B cells occur
Periphery
How do T cells arrive at the Thymus
Immature T cells come from the B marrow
Positive selection
Can the T cell receptor signal
Negative selection
Does it react against our own body
Thymus declines with …
Age
Secondary lymphoid tissues
Spleen]
Lymph Nodes
Appendix
Mucosal associated lymphoid tissue
Secondary lymphoid organ function
Lymphocytes can interact with antigens and other lymphocytes
Lymph nodes info
Arterial and venous connections
Distinct B and T cell zones
What are Peyer’s Patches
Specialised secondary lymphatic tissues found below the epithelium of the ileum of the small intestine
Peyer’s Patches specialisations
Highly enriched w B cells
Contains a high frequency of germinal centres
Germinal centres
Anatomically restricted sites where B cells undergo mutation and selection to generate high affinity antibodies
