Fungal Flashcards
How does amphoterocine B work?
Binds with ergosterol forming a transmembrane channel that leads to monovalent ion (K+, Na+, H+ and Cl) leakage
What are the side effects of amphoterocine B?
Nephrotoxicity
Flu-like symptoms
Hypokalaemia
Hypomagnaseamia
What is a aspergilloma?
Fungus that colonises cavity left behind by e.g. TB
What investigations should aspergilloma?
Rounded opacity. A crescent sign may be present
High antibody precipitins
What is the mechanism of azoles?
Inhibits 14α-demethylase which produces ergosterol
What is the mechanism of amphoteric B?
Binds with ergosterol forming a transmembrane channel that leads to monovalent ion (K+, Na+, H+ and Cl) leakage
What is the mechanism of terbinafine?
Inhibits squalene epoxidase
What is the mechanism of griseofulvin?
Interacts with microtubules to disrupt mitotic spindle
What is the mechanism of flucytosine?
Converted by cytosine deaminase to 5-fluorouracil, which inhibits thymidylate synthase and disrupts fungal protein synthesis
What is the mechanism of caspofungin?
Inhibits synthesis of beta-glucan, a major fungal cell wall component
What is the mechanism of action of nystatin?
Binds with ergosterol forming a transmembrane channel that leads to monovalent ion (K+, Na+, H+ and Cl) leakage
