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Pharmacology > Anti Fungal Part 2 > Flashcards

Anti Fungal Part 2 Flashcards

1
Q

Pharmacokinetics of Azoles

A

Normal one

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2
Q

MOA of Azoles

A

Goal - Inhibition of Conversion of Lonosterol to ergosterol
Inhibition of enzyme C 14 alpha dementhylase…

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3
Q

Resistance in azole is due to

A

Mutations in C 14 alpha dementhylase

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4
Q

If Azoles are teratogenic what should we do

A

Don’t give them to pregnant women

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5
Q

Drug Interactions of azoles

A

These are enzyme inhibitors so shouldn’t be given with drugs catalyzed by those enzymes

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6
Q

Fluconazole least effective has activity against

A

Mold and yeasts type fungi
Candida Albicans
Cryptococcus neoformans

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7
Q

How Fluconazole is used for treatment of Vulvovaginal candidiasis

A

Induction Therapy with Amphotericin B in combination with Flucytosin

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8
Q

What are Terbinafine

A

Squalene epoxide inhibitors

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9
Q

How squalene is related to ergosterol

A

Squalene - Squalene epoxide - Lanosterol - ergosterol

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10
Q

Effectiveness of Terbinafine

A

More effective than Fluconazole

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11
Q

Use of Terbinafine

A

Onchomycosis fungal infection of nails.
Therapy duration is 3 months
Scalp
Groin area
Foot
Ring worm..

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12
Q

Spectrum of Terbinafine

A

Trichophyton
Epidermophyton
Scupulariopsis…

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13
Q

Half life of Terbinafine

A

200 hours so it has slow release

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14
Q

ADRs of Terbinafine

A

Visual and taste disturbance

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15
Q

MOA of Griseofulvin

A

Disruption of Mitotic Spindle Formation
And inhibition of mytosis

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16
Q

Use of Griseofulvin

A

Replaced by oral Terbinafine but used for treatment for fungal infections of hair

17
Q

Pharmacokinetics of Nystatin

A

Not completely absorbed after oral administration
Can’t be given through IV route due to it’s toxic effects… Cause nephrotoxicity

18
Q

Uses of Nystatin

A

Given orally for treatment of Oropharyngeal candidiasis
And
Intra vaginal route for Vaginal Candidiasis

Pharmacology (11 decks)

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