Interferons Flashcards
1
Q
What are interferons
A
Signalling proteins released by host cells in response to the presence of viruses
2
Q
3 major functions of interferons
A
Anti viral
Anti proliferative
Immuno/auto regulatory
3
Q
MOA of interferons
A
Induces host cell ribosome to cause anti viral effect through cellular biochemical processes
4
Q
3 Types of Interferons
A
Aplha 2a
Alpha 2b
Gamma
5
Q
Production of each type of interferons
A
Aplha - leukocyte infected with viruses
Beta - fibroblasts infected with viruses
Gamma - stimulation of sensitised lymphocytes with antigen or non sensitised with mitogens
6
Q
Type 1 Interferons
A
Cytokines which play an important role in inflammation, immunoregulations, tumor cell recognition and T cell responses
7
Q
Type 2 Interferons
A
Immune system regulation.
Only 1 member gamma
