Lung cancers

Question 1

What are the main subtypes of Non small cell lung carcinoma ? (3)

Answer 1

1. Adenocarcinoma
2. Squamocellular
3. Large cell carcinoma

Question 2

What are the frequent mutations of lung adenocarcinoma ?

Answer 2

• Point mutations of small deletions of EGFR (exons 18, 19, 20, and 21)
• Translocation of ALK with numerous partners

Question 3

Type of lung cancer that are mostly associated with mutations of oncosuppresors ?

Answer 3

SCLC (Rb, p53)

Question 4

What risk factor is responsible of 90% of pulmonary tumors?

Answer 4

Cigarette smoking

Question 5

What is the most important exam to do for a px with suspected lung cancer?

Answer 5

Chest CT

Question 6

How do we take biopsy in central lung cancer?

Answer 6

Bronchoscopy

Question 7

How do we take biopsy in peripheral lung cancer?

Answer 7

FNAB with CT guidance

Question 8

Which histotype among the lung cancers is considered to be resistant to chemiotherapy and hard to treat?

Answer 8

Squamocellular lung carcinoma

Question 9

What is the percentage of EGFR mutation in NSCLC patients?

Answer 9

17-20%

Question 10

How do we proceed with treatment in stage II lung cancer that has positive lymph nodes ?

Answer 10

Adjuvant therapy

Question 11

What is the classical chemotherapy used for lung cancer ?

Answer 11

Derivatives of Cisplatin and carboplatin

Question 12

what lung cancer patients will be contraindicated cisplatin ?

Answer 12

Renal insufficient patients, it’s nephrotoxic
and Cardiopathic patients (risk of overload, administered with 2L of water)

Question 13

What is the toxicity of Carboplatin?

Answer 13

Less nephrotoxic than the cisplatin, but it’s myelotoxic

Question 14

What is the target of Bevacizumab ?

Answer 14

targets both endothelial and non-endothelial cells

Question 15

In what isotype of lung cancer we shouldn’t administer Bevacizumb?

Answer 15

Squamous CC

Question 16

in what type of lung cancer and population we find the TKI highly effective ?

Answer 16

Women
Non-smokers, with adenocarcinoma

Question 17

what is the mutation that causes the resistance for the TKI treatment in lung cancers?

Answer 17

T790M of the EGFR gene

Question 18

What drugs are available for lung cancer, targeting the specific mutation T790M of EGFR?

Answer 18

Osimertinib

Question 19

What translocation is common in lung cancer in younger patients, non smokers, with adenocarcinoma ?

Answer 19

ALK-EML4

Question 20

What are The most commonly used immunotherapies for lung cancer ?

Answer 20

Anti PD-1 / PD-L1

Question 21

Drug for ALK translocations in lung cancer?

Answer 21

Crizotinib

Question 22

Drug for BRAF mutation in lung cancer?

Answer 22

dabrafenib