Mabs and Mibs Flashcards
1
Q
Natalizumab
A
Alpha 4-integrin antagonist
Indications:
Multiple sclerosis
Risks:
PML (JC virus)
2
Q
Ocrelizumab
A
Anti-CD20 cytolytic antibody
3
Q
Alemtuzumab
A
Anti-CD52 (B cells)
Indications:
Multiple sclerosis
Risks:
ITP
Autoimmune thyroid disease
Cannot give live vaccines
4
Q
Imatinib
A
Tyrosine kinase inhibitor
5
Q
Dabrafenib
A
BRAF inhibitor
6
Q
Sunitinib
A
Protein kinase inhibitor
(VEGFR, PDGFR)
7
Q
Dasatinib
A
TKI, Philadelphia Chromosome (Bcr/Abl)
8
Q
Nilotinib
A
TKI, Philadelphia Chromosome (Bcr/Abl)
9
Q
Osimertinib
A
Anti-EGFR
10
Q
Rituximab
A
Anti-CD20
Risks:
HBV
11
Q
Eculizumab
A
Anti-C5
Indications:
PNH
Risks:
Neisseria infections
12
Q
Daratumumab
A
Anti-CD38
Indications:
MM
13
Q
Mepolizumab
A
Anti-IL5
Indications:
Asthma
Eosinphilic granulomatosis with polyangitis
14
Q
Trastuzumab
A
Anti-HER2
15
Q
Pertuzumab
A
Anti-HER2
