Anatomy of Immune Response Flashcards
neutrophils
first to arrive, ingest antigens/pathogens, die rapidly following clearance, highly potent
3 types of polymorphonuclear (PMN) leukocytes
neutrophils, eosinophils, basophils
antigen presenting cells
macrophages, dendritic cells, B and T cells
APC for exogenous antigens
antigen is ingested and broken into peptides –> peptides bind MHC-II –> MHC-II complex presents to CD4 T cells
APC for endogenous antigens
viral mRNA is converted to protein –> broken into viral peptides –> peptides bind to MHC-I –> MHC-I complex presents to CD8 T cells
dendritic cells
powerful antigen-presenting cells primarily involved in INITIATING immune responses; function primarily in secondary lymphoid organs
macrophages
powerful APC’s; primarily involved in ACTIVATING EXISTING immune responses; function primarily at sites of infection
B lymphocyte
B cell + antigen –> antibody secretion
helper T lymphocyte
helper T cell + APC –> cytokine secretion for inflammation and activation of macrophages/lymphocytes
cytotoxic T cell
cytotoxic T cell + target cell with antigen –> lysis
natural killer cells
technically part of innate response because they have no memory; large granular lymphocytes
primary lymphoid organs
fetal liver, bone marrow, thymus
Where do NK cells mature?
bone marrow
Where do myeloid cells mature?
bone marrow
Where do T cells mature?
thymus
