Hematopoiesis Flashcards
defining property of stem cells
self-renewal
multipotent stem cells
can give rise to multiple types of differentiated progeny cells
unipotent stem cells
can give rise to only one type of differentiated progeny cells
induced pluripotent stem cells
de-differentiate skin fibroblasts –> induce pluripotency –> differentiation into desired cell type
blood stem cells can _
self-renew, become platelets, WBC’s, and RBC’s
development of mature cells
stem cells –> progenitor cells –> precursor cells –> mature cells
stem cell properties
high self-renewal, low proliferation, high potential (can become anything)
progenitor cell properties
not much self-renewal, some proliferation, high potential
precursor cell properties
no self-renewal, high proliferation, one potential
mature cell properties
no self-renewal, some proliferation, one potential
pluripotent hematopoietic stem cell gives rise to _
common lymphoid and common myeloid progenitors
common lymphoid progenitors give rise to _
B cell, T cell, and NK cells in the blood
common myeloid progenitors give rise to _
granulocyte/macrophage progenitors and megakaryocyte/erythrocyte progenitors
erythrocyte progenitors give rise to _
platelets and erythrocytes
granulocyte/macrophage progenitors give rise to _
neutrophils, eosinophils, basophils, mast cell precursor, monocytes (in blood)
