12.4 - Non-specific Animal Defences: Phagocytosis Flashcards
(10 cards)
Neutrophils
These rapidly engulf and destroy pathogens at the site of infection
Macrophages
These engulf and digest pathogens but also present the pathogen’s antigens on its cell surface to activate other cells in the immune system
1
The pathogen releases chemicals that attract a phagocyte
2
The phagocyte recognises the pathogen’s antigens as non-self. This causes the phagocyte to bind to the pathogen
3
The phagocyte engulfs the pathogen
4
The lysosome, containing hydrolytic enzymes called lysozymes, fuses with the phagosome to form a phagolysosome
6
The phagocyte presents the pathogen’s antigens on its surface to activate other cells in the immune system. The phagocyte is then referred to as an antigen-presenting cell
Cytokines
- Chemicals released by phagocytes that engulfed the pathogen
- ## Cell signalling
Opsonins
- Chemicals (e.g. antibodies) that bind to pathogens to make them easily recognisable by phagocytes