B1 anatomy of immunity

Question 1

the life of a t cell

Answer 1

-selected in thymus
-matures and migrates into the periphery
-circulates through lymph nodes
-if it recognises antigen, activates effector function

Question 2

peripheral lymphoid organs

Answer 2

adenoid
tonsil
right subclavian vein
left subclavian vein
thymus
lymph node
heart
thoracic duct
kidney
spleen
peyers patch in small intestine
large intestine
appendix
bone marrow
lymphatics

Question 3

what happens when T cell enter lymph node cortex

Answer 3

enter lymph node cortex from blood via high endothelial venules (HEVs)
T cells not activated by antigen presented by dendritic cells exit from lymph node via cortical sinuses
-migrate through secondary tissues
-sample peptide:MHC complexes on dendritic cells

Question 4

3 stages of lymphocytes and how they respond to antigen in peri lymphoid organs

Answer 4

-naive lymphocytes enter lymph nodes from blood
-antigens from sites of infection reach lymph nodes via lymphatics
-lymphocytes and lymph return to blood via the thoracic duct

Question 5

T cell receptor function

Answer 5

-2 protein chains paired together
often α and β​
Sometimes γ and δ
-variable regions
recognises diversity
-transmembrane with cytoplasmic tail
signlling upon recognition

Question 6

what happens if t cell recognises antigen MHC

Answer 6

-t cell and antigen presenting cell form interaction
-tcr transmits signals and t cell becomes activated

Question 7

the 3rd and 4th dimension?

Answer 7

-adaptive immune system takes time to respond
-immune responses occur in diff locations
-requires cells to move, interact and produce cytokines to influence effector function