Pancreatic Disease Flashcards

1
Q

What are the typical histopathological changes observed in a) acute and b) chronic pancreatitis

A

a) Oedema, neutrophilic infiltrate, necrosis
b) Fibrosis

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2
Q

Which breeds are predisposed to chronic pancreatitis?

A

CKCS, Cocker Spaniels, Boxers, Collies

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3
Q

What infectious disease has been associated with AP?

A

Babesiosis

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4
Q

In a necropsy study of 200 dogs, how many had a) macroscopic and b) microscopic signs of pancreatitis?

A

a) 8%
b) 30%

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5
Q

What is the sensitivity/specificity of total lipase for canine pancreatitis?

A

50/50

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6
Q

What is the effect of experimentally induced CKD on CPLi in dogs?

A

Increases but usually not above RR

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7
Q

Which drugs have been associated with pancreatitis in dogs?

A

KBr, Phb, Ca++, L-asparaginase

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8
Q

What were the findings of a study comparing enteral and parenteral nutrition in dogs with AP?

A

No difference in mortality
Faster recovery in dogs fed enterally

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9
Q

What is the MOA of maropitant?

A

NK1 inhibitor - blocks substance P

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10
Q

What is the MOA of ondansetron?

A

5HT3 antagonist

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11
Q

Which breed of dog has been reported to have chronic pancreatitis with features of autoimmune pancreatitis?

A

Cocker Spaniel

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12
Q

What are biochemical indicators of severe pancreatitis in cats?

A

Hypoalbuminaemia and hypocalcaemia

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13
Q

Why is dietary fat restriction NOT recommended in cats with pancreatitis?

A

They have a high constitutive requirement for arachidonic acid

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14
Q

What are the most common causes of EPI in dogs and cats?

A

Chronic pancreatitis (dogs and cats)
Pancreatic acinar atrophy (dogs)

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15
Q

What breeds of dog are affected by pancreatic acinar atrophy?

A

GSD, rough-coated Collies and Eurasians

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16
Q

What risk factors have been identified for pancreatic neoplasia in dogs?

A

Airedale Terriers
Females

17
Q

What paraneoplastic sign is associated with pancreatic neoplasia in cats?

A

Alopecia, most prominent on ventral abdomen.

18
Q

What routine biochemical changes should lead to a suspicion of pancreatic of hepatic neoplasia?

A

Marked elevation in lipase with minimal change in amylase

19
Q

What % of pancreatic carcinoma stain positive for COX-2?

A

25%