2- NSAIDs Flashcards
Give an example of a commonly used NSAID in small animals
SA = Meloxicam, Carprofen, Robenacoxib
Action of NSAIDS
Inhibit COX enzymes = Results in inhibition of prostanoids synthesis in inflammatory cells
Decrease in PGE2/PGI = reduces vasodilation & oedema
Analgesic effect
Anti-pyretic effect
Describe the mechanism of how NSAIDS have an anti-pyretic effect?
Interleukin 1 releases PG in the CNS = elevate hypothalamic set point causing fever
NSAIDs act on COX2 enzyme decrease production of PG
Do NSAIDS have high plasma protein bonding?
Yes
Common adverse effects of NSAIDS
GI disturbance = ulceration & bleeding
Cardiovascular effects = related to COX2 inhibition in the kidney = hypertension
Reversible renal insufficiency
Bronchospasms
A new NSAID ‘grapiprant’ works differently to others. What is its mode of action?
Selective antagonist of the EP4 receptor (mediates PGE2 induce nociception)
T/F You can administer NSAIDS concurrently/ within 24 hours of each other
FALSE - Do not - need a period of time if changing NSAID
Give an example of a commonly used NSAID in equine
EQ = Meloxicam, Phenylbutazone, Flunixin meglumine
Give an example of a commonly used NSAID in farm animals
FA = Meloxicam, Ketoprofen
Where are NSAIDs generally excreted
in the liver and partially via the kidney
T/F you can use Phenylbutazone in cats
False
What is carprofen good to use for
post-op pain and inflammation
reduction of chronic inflammation
What is ketoprofen good against
acute pain and chronic pain from osteoarthritis
What is flunixin good for
alleviation of inflammation and pain associated with MSK, resp and GI disorders
How is galiprant excreted
Via the faeces but some renally
